August 2010

Meeting Theme: Metabolism and Disease

Metabolism and Disease


Session: Mitochondrial Function and Disease
Beneficial Effects of Increased Mitochondrial Biogenesis in Aging, Carlos Moraes, University of Miami Miller School of Medicine

Revisiting the Role of Mitochondrial ROS in Aging and Age-dependent Diseases Transfer Proteins, Siegfried Hekimi, McGill University

Metabolic Regulation of Mitochondrial Dynamics, Orian Shirihai, Boston University

Session: Metabolic Communication
Redox Analysis and Metabolic State, Dean P. Jones, Emory University

The Role of Cell-specific Clocks in Metabolism and Disease, Molly S. Bray, University of Alabama at Birmingham

Abdominal Obesity, Fatty Acids and Insulin Resistance, Richard Bergman, University of Southern California Keck School of Medicine

Session: Metabolic Signal Transduction
Lipid Cycling as a Signal in β-cells, Marc Prentki, University of Montreal

Signaling by ROS in β-Cells and Fat Cells, Barbara E. Corkey, Boston University School of Medicine

NAD and Cofactors in the Control of Metabolism, Johan Auwerx, École Polytechnique Fédérale de Lausanne

Session: Metabolism and Cancer
Metabolic Mutations that Cause Cancer, Craig B. Thompson, University of Pennsylvania

Regulation of Tumor Cell Survival under Metabolic Stress, Tak W. Mak, University of Toronto

Role of p53 in Metabolism and Invasion, Karen H. Vousden, Beatson Institute for Cancer Research

Workshop: New Tools to Study Mitochondrial Function
Chair: Orian Shirihai, Boston University

Lastly, Richard Bergman (University of Southern California) will talk about how free fatty acids, and the pattern of free fatty acid release, regulates glucose homeostasis. He also will examine the possible consequences of free fatty acid release on the sympathetic nervous system in the obese or insulin-resistant state.

Signal Transduction

The third symposium, titled “Metabolic Signal Transduction,” will concentrate on mechanisms by which metabolic changes within the cell are translated into signals that modulate functions, from secretion to metabolism to transcriptional regulation. Marc Prentki (University of Montreal) will discuss the biochemical basis of β-cell signaling in response to glucose, amino acids and fatty acids, as well as β-cell nutrient detoxification and the emerging role of glycerolipid/fatty acid cycling in these processes.

Next, Barbara E. Corkey (Boston University School of Medicine) will compare different fuel-induced signals in fat and β-cells with a focus on how the same signals subserve different cell-specific but complementary functions.

Johan Auwerx (École Polytechnique Fédérale de Lausanne) will then describe how protein acetylation-deacetylation reactions affect wide-ranging physiological processes, with a particular focus on the NAD dependent deacetylase SIRT-1. He will develop the concept that boosting cellular levels of NAD+ may ameliorate factors associated with the metabolic syndrome.

Cancer

The fourth and final symposium, “Metabolism and Cancer,” will look at how altered metabolism can promote oncogenic pathways and tumor cell survival. Craig B. Thompson (University of Pennsylvania) will review his work on the role of glycolytic and Krebs cycle enzymes in controlling the production of metabolites with oncogenic or tumor suppression capabilities.

Next, Tak W. Mak (University of Toronto) will discuss how metabolic stress can influence various apoptotic pathways and cancer cell survival.

And, finally, Karen H. Vousden (Beatson Institute for Cancer Research in Glasgow) will discuss insights into the signaling and metabolic pathways involved in tumor cell invasion and the role played by p53 in metastasis.

Workshop

We also have scheduled a workshop, titled “New Tools to Study Mitochondrial Function” and chaired by Orian Shirihai (Boston University). Speakers at this event will demonstrate new ways to monitor bioenergetics, mitochondrial function and ROS and mitochondrial dynamics (fusion, fission and morphology) in vivo. 

Barbara E. Corkey (bcorkey@bu.edu) is director of the Obesity Research Center and a professor of medicine and biochemistry at the Boston University School of Medicine. Marc Prentki (marc.prentki@umontreal.ca) is a professor of nutrition and biochemistry and Canada research chair in diabetes and metabolism at the University of Montreal.

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