August 2010

Meeting Theme: Metabolism and Disease


The "Metabolism and Disease" annual meeting theme will cover mitochondrial dysfunction, information transmission, signal transduction and cancer. There also will be a special workshop, titled “New Tools to Study Mitochondrial Function.” The meeting will be held April 9-13, 2011, in Washington, D.C. (Titled "Communications of the Metabolic State" in print version.)


Meetings---Corkey Meetings---Prentki
Barbara E. Corkey Marc Prentki

Metabolic regulation represents the front line in the control of intermediary metabolism as well as transcriptional and protein synthetic adaptation to changes in the cellular environment. The increased sensitivity of analytical tools and recent advances in molecular genetics and imaging have fostered greater understanding of interconnections between metabolic networks and the diverse molecular mechanisms involved in cellular functions. As a result, “classical” intermediary metabolism has been found to be involved directly in signaling functions as diverse as apoptosis, cell growth and transcriptional control, which impact not only the single cell, but all basic physiological processes.

The 2011 American Society for Biochemistry and Molecular Biology annual meeting “Metabolism and Disease” theme consists of four symposia that focus attention on novel roles of mitochondria in diseases, metabolic communication among various organs, mechanisms of metabolic signal transduction within the cell and the rekindled awareness of the important role of metabolism in cancer.

Mitochondrial Dysfunction

The first symposium, titled “Mitochondrial Function and Disease,” will look at diseases directly related to mitochondrial dysfunction. Carlos Moraes (University of Miami) will discuss his experience with patients affected by mitochondrial oxidative phosphorylation disorders. He also will consider the various options that may improve respiration and ATP production in these patients’ cells.

Next, Siegfried Hekimi (McGill University) will present research that challenges our current thinking about the role of increased mitochondrial ROS production in aging.

And, finally, Orian Shirihai (Boston University) will discuss mitochondrial fission, fusion and networking and consider the heterogeneity of mitochondria in terms of structure and function and association with a number of diseases, including ischemia-reperfusion and nutrient-induced pancreatic β-cell dysfunction in diabetes.

Information Transmission

Click here for more 2011 annual meeting thematic overviews.

For information on  annual meeting registration, housing and abstract submission, click here.

The second symposium, titled “Metabolic Communication,” will focus on mechanisms by which metabolic information is transmitted from one organ to another via the extracellular thiol redox state, clock proteins and free fatty acids. Dean P. Jones (Emory University) will discuss the connection between the redox potential of plasma cysteine/cystine and the risk factors for cardiovascular disease, namely age, smoking, type 2 diabetes, obesity and alcohol abuse. Data show that the proinflammatory effects of the oxidized plasma redox state are due to a mitochondrial signaling pathway that is mediated through redox control of downstream effector proteins.

Molly S. Bray (University of Alabama at Birmingham) will then explain how biological rhythms profoundly influence energy homeostasis and also how carbohydrate or fat consumption at a given time of the day may influence health.


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