July 2010

Controling Toxic Chemicals: The European Union's REACH Legislation

The changes to toxicology testing methods and analysis ultimately will be defined by a concomitant increase in our understanding of underlying toxicological principals, the continued development of effective in vivo and in vitro test platforms and computational modeling capabilities and finally an acceptance of the new risk assessments by the community, regulatory authorities and industry.

References

1. Hartung, T. (2009) Toxicology for the Twenty-first Century. Nature 460, 208–212.

2. Lahl, U., and Gundert-Remy, U. (2008) The use of (Q)SAR Methods in Context of REACH. Toxicology Mechanisms and Methods 18, 149–158.

3. Hartung, T. (2009) Pathway Based Approaches: A European/REACH Perspective. Toxicity Pathway-Based Assessment: Preparing for Paradigm Change, a Symposium of the Standing Committee on Risk Analysis Issues and Reviews— May 11–13, 2009.  National Research Council, Washington, D.C.

4. Preuss, P. W. (2009) The Changing Landscape of Risk Assessment. Toxicity Pathway-Based Assessment: Preparing for Paradigm Change, a Symposium of the Standing Committee on Risk Analysis Issues and Reviews. May 11–13, 2009.  National Research Council, Washington, D.C.

5. Schmidt, C. W. (2009) Tox 21: New Dimensions in Toxicity Testing. Environmental Health Perspectives 117, A349–A353.

6. Thomas, R. S., et al. (2001) Identification of Toxicologically Predictive Gene Sets Using cDNA Microarrays. Mol. Pharmacol. 60, 1189–1194.

7. Bhogal, N., et al. (2005) Toxicity Testing: Creating a Revolution Based on New Technologies. Trends in Biotechnology 23, 299–307.

Tertius de Kluyver (dekluyver@hood.edu) is an adjunct professor of biology and environmental science at Hood College.

NEXT PAGE 1 | 2

First Name:
Last Name:
Email:
Comment:


Comment on this item:
Rating:
Our comments are moderated. Maximum 1000 characters. We would appreciate it if you signed your name to your comment.


  


There aren't any comments on this item yet. Tell us what you think!

0 Comments

Page 1 of 1

found= true858