Fundamental and applied progress in biological therapies depends on understanding chemical biology. The “Chemical Biology and Drug Discovery” theme, organized by Shana O. Kelley (University of Toronto) and Tamara L. Hendrickson (Wayne State University), covers topics for both novice and seasoned investigators. Sessions will include lectures on the chemical biologist’s toolbox; peptide-based drug delivery; drug discovery and biomaterials; novel approaches to high throughput drug discovery; and the chemical biology of human disease.
The biochemistry of RNA is a classic, as well as a new, topic. For the “Biochemistry of RNA” theme, E. Stuart Maxwell (North Carolina State University) and Tina M. Henkin (Ohio State University) have organized presentations on recent discoveries of RNA-based gene regulation in bacteria; RNA editing and nucleotide modification; RNA/RNP transport and localization and small RNA regulation of mRNA translation. RNA research has become a fast paced area, and the thematic talks promise to be very stimulating and thought-provoking.
Complementing the RNA theme is a “DNA Replication, Recombination and Repair” theme. Joann B. Sweasy (Yale University School of Medicine) and Marlene Belfort (Wadsworth Center, New York State Department of Health) will chair this symposium. They will select speakers to provide insight on aberrant DNA repair; genomic instability and cancer; site-specific recombination in chromosome dynamics and gene therapy; replication of non-canonical DNA sequences and genomic instability and retroelements in genome plasticity and cancer. If you are interested in DNA research, you won’t want to miss these talks.
Qiang Zhou (University of California, Berkeley) and Karolin Luger (Howard Hughes Medical Institute/Colorado State University) will spearhead the “Biochemistry of Transcription and Chromatin Structure/Organization” theme. They have put together a program encompassing new concepts of RNA polymerase pausing and elongation; transcriptional regulation in cell growth, differentiation and disease; the mechanisms of structural transitions in chromatin and alternative chromatin structures.
And finally, the ASBMB Minority Affairs Committee is sponsoring a special symposium on obesity. The lecture series, titled “The Frontiers in Obesity Research,” will explore system physiology modeling of human metabolism and body weight changes; the quantification and therapeutic potential of brown adipose tissue; the biochemistry of addiction; cardiac complications of obesity and the potential use of dietary garlic to prevent the development of, or alleviate, obesity and diabetes in mice. There also will be lectures on strategies for obesity prevention; the role of stearoyl-coA desaturase in energy metabolism; the adipose renin-angiotensin system; obesity and insulin resistance and adipokine regulation of energy and glucose homeostasis.
Topical and Technical Workshops
We also have organized a workshop in collaboration with the Chemical Biology and Drug Discovery and Metabolism and Disease theme. The workshop will focus on mitochondrial-metabolic defects and chemical strategies for addressing these problems. Another workshop on transcription and chromatin also is being planned.
Exploring Educational Challenges
Each year, the Education and Professional Development Committee offers programming that explores educational challenges. For 2011, the committee has organized a session titled “It Didn’t Work! Coping with ‘Failure’ for Students and Professionals.” This symposium will cover ways to foster interactions between college and university scientists and high schools; how to deal with frustrations at the bench; developing classroom management skills; mentoring students in the research laboratory and the art of collaboration. These topics especially should appeal to the young scientists and their teachers.
Look for more information on the individual themes and award lectures in future issues of ASBMB Today. Additional details on all the activities planned for the 2011 meeting and how to register and submit abstracts will also be forthcoming.
Daniel M. Raben (firstname.lastname@example.org) is director of the ASBMB Lipid Division and also a professor in the department of biological chemistry at the Johns Hopkins University School of Medicine. Kuan-Teh Jeang (email@example.com) is chief of the molecular virology section of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.