Lingrel is thrilled that his work has helped so many other scientists. Although he’s focused primarily on the vascular system, both KLF2 and the Na,K-ATPase are fairly ubiquitous, and his fundamental discoveries are applicable to areas like muscle activity, neuroscience and development. And, not surprisingly, he’s been flooded with requests for advice or one of his many transgenic mouse lines, which he’s always happy to oblige.
One cannot help but wonder whether it’s perfectly fitting or somewhat ironic that this calm and contented man is revealing the mechanisms of atherosclerosis and hypertension.
Lockard, R. E., and Lingrel, J. B. (1971) Identification of Mouse Haemoglobin Messenger RNA. Nature, 233, 204–206.
Shull, G. E., Schwartz, A., and Lingrel, J. B. (1985) Amino-acid Sequence of the Catalytic Subunit of the (Na+/K+) ATPase Deduced from a Complementary DNA. Nature, 316, 691–695.
Anderson, K. P., Kern, C. B., Crable, S. C., and Lingrel, J. B. (1995) Isolation of a Gene Encoding a Functional Zinc Finger Protein Homologous to Erythroid Krüppel-like Factor: Identification of a New Multigene Family. Mol. Cell. Biol. 15, 5957–5965.
Woo, A. L., James, P. F., and Lingrel, J. B. (2000) Sperm Motility Is Dependent on a Unique Isoform of the Na,K-ATPase. J. Biol. Chem. 275, 20693–20699.
Dostanic-Larson, I., Van Huysse, J. W., Lorenz, J. N., and Lingrel, J. B. (2005) The Highly Conserved Cardiac Glycoside Binding Site of Na,K-ATPase Plays a Role in Blood Pressure Regulation. Proc. Natl. Acad. Sci. U.S.A. 102, 15845–15850.
Huddleson, J. P., Ahmad, N., and Lingrel, J. B. (2006) Up-regulation of the KLF2 Transcription Factor by Fluid Shear Stress Requires Nucleolin. J. Biol. Chem. 281, 15121–15128.
Nick Zagorski (email@example.com) is a science writer at ASBMB.