January 2010

JBC Wishes PEPCK a Happy Anniversary!

For more information

• The PEPCK 55th anniversary collection can be found at www.jbc.org/site/thematics/pepck, where it is also available for print purchase.

Hanson, who in addition to contributing to the minireview series helped coordinate the JBC compendium, notes that, despite 55 years of research on the mechanisms, metabolism and molecular biology of PEPCK, many gaps in our knowledge still remain. However, he said he is confident that research on the fascinating enzyme shows no signs of slowing down, and he’s looking forward to celebrating many more PEPCK anniversaries in the future.

Nick Zagorski (nzagorski@asbmb.org) is a science writer at ASBMB.


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This PEPCK series is great! It brings lots of happy memories of PEPCK during my association with Richard Hanson and Merton Utter. It was my good fortune to work as a colleague with these two PEPCKers. My first encounter with PEPCK was in Hanson’s laboratory at Fels Research Institute at Temple University School of Medicine in late the sixties where I was a postdoctoral fellow working on the role of pyruvate carboxylase (Utter’s other major contribution in biochemistry). After enjoying nearly 10 years of PEPCK development in Hanson’s lab (working next door as a colleague), I moved with Richard Hanson when he moved as the chair of the Department of Biochemistry at Case Western Reserve University (assuming the position vacated by Merton Utter!). It was my good fortune that I had two PEPCKers as my colleagues for some time! Unfortunately, Dr. Utter passed away after a few years, but I continued to work under Hanson’s PEPCK umbrella for 15 years. If that is not enough good fortune for me under the PEPCK umbrel



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