February 2013

The uses of metabolic adversity

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Sweet are the uses of adversity.
—William Shakespeare
             “As You Like It” 
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Blurred vision was the first sign that something was wrong. The front row of the freshman chemistry class I was teaching looked strangely fuzzy. Then, over the next few days, I was gripped by an unquenchable thirst and was constantly fatigued. Seemingly overnight I lost eight pounds. I recognized the symptoms of diabetes, but I was young(ish), slim(ish) and an avid kick-boxer. Mine was not the typical diabetic profile.

Despite my suspicion that I was experiencing raging hyperglycemia, the diagnosis — “You have diabetes” — was devastating. It marked the beginning of a lifestyle that is an enormous challenge. However, the journey has led me to an increased understanding of biochemistry, has enhanced my teaching and ultimately has cast me in a new role of helping others.

It turned out that I had developed latent autoimmune diabetes in adults, or LADA, a subset of type 1 diabetes. LADA is due to an autoimmune reaction to pancreatic glutamate decarboxylase, or GAD65. While LADA has a slower onset than classic type 1, formerly known as juvenile diabetes, the two diseases follow a similar course and require injections of insulin.

Fortunately, I felt equipped to manage my condition. I teach metabolism to undergraduates using an approach that emphasizes insulin-dependent pathways as a unifying theme and one that offers an everyday context. I knew that carbohydrates, whether whole grain or highly processed, could raise my blood glucose to dangerous levels, so my response to the diagnosis was to reduce greatly carbohydrates in my diet. In addition, I was careful to monitor my blood sugar levels and insulin doses. The result was that my hemoglobin A1c (glycosylated hemoglobin, a measure of blood sugar control), was 5.4 percent, within the normal 4 percent to 5 percent range. My doctor said that I was his “best patient ever” and that I was achieving the blood sugars of a nondiabetic person.

Despite satisfaction with my glycemic control, my physician wanted me to see a dietitian. To my surprise, the dietitian was appalled by my diet. She said, “You have to eat a minimum of 130 grams of carbohydrates a day.” I protested, but she recruited the rest of the medical team to endorse her position: “We all say you have to eat more carbs. The American Diabetes Association gives us these guidelines.” One member of the team said, “I want you to eat chocolate. I want you to enjoy life.”

As someone raised to be cooperative, and because I found it easy to embrace medical advice to eat chocolate, I agreed to eat more carbohydrates. The result was that my HbA1c rose above 7 percent. My blood sugar levels were frequently in the 200 to 300 mg/dl range (far above the normal level of about 85 mg/dl), even when I supplemented with extra insulin. My former dose of seven units of insulin per day increased to 30 units per day. The loss of control was immensely frustrating. My physician attributed my initial success to what is called the diabetes honeymoon. Often, when someone first begins taking insulin, there is a short-lived period during which β-cells seem to recover a bit and secrete insulin. Regardless, it was clear that the dietitian’s approach was not yielding the success I desired. I felt confused and uncertain as to what to do.

I decided to investigate for myself what my best diet should be. I studied the literature, I sought out researchers and physicians, and I attended countless metabolism-related talks. In addition, I connected with hundreds of people with diabetes. The most important contribution to my achieving clarity, however, was evaluating literature based on a molecular understanding of how metabolism works.

In my quest for answers, I found to my surprise that many dietitians and physicians were unable to explain the basis for the dietary recommendations they endorsed. Some did, however, express a desire for a better understanding or review of what they’d once learned. And in the general public, I encountered scores of diabetics and nondiabetics who also wanted tools to make sense of conflicting nutritional information.

I began to use what I had learned not only to expand and improve my teaching and research but also to step into the role of a nutrition explainer. First I was determined to see that none of my students would lack understanding of processes such as gluconeogenesis and the many pathways affected by insulin. I created new lecture topics and problem sets based on diabetes and nutrition applications. My students responded positively and appreciatively. There was a palpable increase in attention in class. Students came to my office to chat about things that they had read. My class evaluations praised the use of nutritional context and often said, “This material could have been rather dull without all these great applications.” I even heard (frequently) “I love metabolism!”

Click here to read ASBMB Today editor Angela Hopp’s note about this new essay series.

Beyond my student population, I engaged a world of bloggers, physicians and other people with diabetes, many of whom were eager to understand more deeply how things work metabolically. I now find myself being interviewed, quoted in papers, and invited to speak to groups of people, including physicians, who want to deepen their understanding of metabolic pathways. I am asked to share my nutrition-based teaching applications with other professors and with textbook publishers. In these efforts, I try to avoid dispensing nutritional advice; instead, I attempt to show how nutrient composition affects metabolic pathways so that my audience feels better able to evaluate nutritional recommendations.

Five years later, diabetes is still an immense mental and physical challenge, but I am grateful for the insight and tools that my education and training have provided me. Most importantly, if I am able to further the use of molecular science to help others find optimal dietary strategies, and if I can help the next generation, then my adversity will have had a positive outcome.

Wendy Knapp PogozelskiWendy Knapp Pogozelski (pogozels@geneseo.edu) earned a B.S. from Chatham University and a Ph.D. in chemistry from Johns Hopkins University under the direction of Thomas Tullius. She spent two years as an Office of Naval Research postdoctoral fellow working at various sites in radiation biology. She is a professor of chemistry at the State University of New York (SUNY) College at Geneseo, where she has been since 1996. She teaches biochemistry, emphasizing medical and nutrition-based applications. Her current research focuses on radiation effects on mitochondrial function and mitochondrial DNA as well as on understanding how dietary strategies affect biochemical pathways.

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