February 2012

Adipose tissue de novo lipogenesis

Thus, growing evidence suggests that increasing adipose tissue DNL may provide beneficial health effects in contrast with the effects of DNL in liver tissue. Strategies to enhance DNL specifically in adipose tissue and to identify and administer salutary bioactive lipids may provide new therapies for metabolic and cardiovascular disease.

References
  1. 1. Cao, H., et al. (2008) Cell. 134:933 – 944.
  2. 2. Wang, Y., et al. (2006) Journal of Lipid Research. 47:2028 – 2041.
  3. 3. McDevitt, R.M., et al. (2001) The American Journal of Clinical Nutrition. 74:737 – 746.
  4. 4. Herman, M.A., Peroni, O.D., Kahn, Barbara B. (2009) Diabetes. 58: suppl. 1, A351.
  5. 5. Postic, C. and Girard, J. (2008) J. Clin. Invest. 118:829 – 838.
  6. 6. Hudgins, L.C., Parker, T.S., Levine, D.M., Hellerstein, M.K. (2011) Journal of Clinical Endocrinology & Metabolism. 96:861 – 868.
  7. 7. Roberts, R., et al. (2009) Diabetologia. 52:882 – 890.
  8. 8. Dentin, R. (2006) Diabetes. 55:2159 – 2170.
  9. 9. Shimano, H., et al. (1997) J. Clin. Invest. 100:2115 – 2124.
  10. 10. Kuriyama, H., et al. (2005) Cell Metabolism. 1:41 – 51.
  11. 11. Heilbronn, L.K., Ravussin, E. (2003) The American Journal of Clinical Nutrition. 78:361 – 369.
  12. 12. Bruss, M.D., Khambatta, C.F., Ruby, M.A., Aggarwal, I., Hellerstein, M.K. (2010) American Journal of Physiology – Endocrinology and Metabolism. 298:E108 – E116.
lipid_news_hermanlipid_news_kahn

Mark A. Herman (mherman1@bidmc.harvard.edu) is an instructor of medicine at Harvard Medical School and a faculty member in the Division of Endocrinology, Diabetes and Metabolism at Beth Israel Deaconess Medical Center.  Barbara B. Kahn (bkahn@bidmc.harvard.edu) is the George R. Minot professor of medicine at Harvard Medical School, vice chair for Research Strategy in the department of medicine, and former chief of the Division of Endocrinology, Diabetes and Metabolism at Beth Israel Deaconess Medical Center.

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COMMENTS:

Great article! I have read consistent data indicating that DNL does not contribute to overall obesity and body weight changes. Your review builds upon this, offering suggestions that enhanced adipose DNL may even improve insulin sensitivity, glucose homeostatis and consequently body composition. Aric Sudicky, B.Sc., B.Ed, CPTS, CFNS MEDPOINT Director of Fitness and Nutrition 2011 Canadian Fitness Professional of the Year Educate.Motivate.Inspire http://www.facebook.com/AricSudicky.EducateMotivateInspire

 

I like this article very much, particularly these two figures. I wonder if I could get the ppt file for Figures 1 and 2. Thanks. Jianqiang Mao, Ph.D.(ASBMB member) Department of Molecular and Cellular Biology Baylor College of Medicine One Baylor Plaza Houston, TX 77030 Email: jmao@bcm.edu

 

 

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