Thus, growing evidence suggests that increasing adipose tissue DNL may provide beneficial health effects in contrast with the effects of DNL in liver tissue. Strategies to enhance DNL specifically in adipose tissue and to identify and administer salutary bioactive lipids may provide new therapies for metabolic and cardiovascular disease.

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Mark A. Herman (mherman1@bidmc.harvard.edu) is an instructor of medicine at Harvard Medical School and a faculty member in the Division of Endocrinology, Diabetes and Metabolism at Beth Israel Deaconess Medical Center.  Barbara B. Kahn (bkahn@bidmc.harvard.edu) is the George R. Minot professor of medicine at Harvard Medical School, vice chair for Research Strategy in the department of medicine, and former chief of the Division of Endocrinology, Diabetes and Metabolism at Beth Israel Deaconess Medical Center.