Clever cytokine work
|Niamh Mangan was named a Tabor award winner at the International Society for Interferon and Cytokine Research meeting held in October in Florence, Italy, and attended by Journal of Biological Chemistry Associate Editors Charles Samuel and Luke O'Neill.
|| Solenne Vigne was named a Tabor award winner at the International Cytokine Society’s meeting held in October in Florence, Italy, and attended by Journal of Biological Chemistry Associate Editors Charles Samuel and Luke O'Neill.
Niamh Mangan and Solenne Vigne were named winners of Tabor awards at a joint meeting of two organizations dedicated to cytokine and interferon research.
Mangan, a postdoctoral fellow at Monash University in Australia, was recognized for her work on the role of interferon cytokine and receptor signaling in immune regulation in infection and inflammation – and, more specifically, the characterization of the cytokine interferon epsilon, which may be important for infections in the female reproductive tract.
Mangan earned her Ph.D. in 2005 at Trinity College Dublin, where she studied the cellular mechanisms of modulation and suppression of the immune response using mouse models, and she completed a postdoctoral stint at Trinity College before being recruited to work in Australia with Paul Hertzog at the Monash Institute of Medical Research in Melbourne.
Solenne Vigne, a postdoc at the University of Geneva, was recognized for her work showing that IL-36 cytokines exert stimulatory effects on dendritic cells and T helper cells, leading to a predominant type 1 helper response in vitro and in vivo.
“These results demonstrate for the first time a critical role for these cytokines in the stimulation of innate and adaptive immune responses,” Vigne says. “Therefore, our findings indicate that these cytokines may represent potential targets for immune-mediated inflammatory conditions.”