December 2011

Five years of giving rural students second chances

Billy Hudson’s life continues to inspire the Aspirnaut Initiative for K – 12 STEM education.

At the age of 64, Billy G. Hudson, a renowned expert in the molecular basis of kidney diseases, one day returned to his rural Arkansas hometown after an absence of 50 years and got on a yellow school bus. Hudson wanted to help the children in his childhood community but had no idea how to go about it. He decided to ride the school bus. “I don’t know why I did it,” he says.

Children riding a school bus in rural Arkansas take in science lessons played on the TV screens installed in the bus.

It was a chilly October morning in 2005, still dark at 6 a.m., when Hudson climbed up the bus stairs to start the one-and-half-hour trip to the local school on the street he lived on as a child. The bus jolted over gravel roads and went past densely wooded areas with only the occasional glimpse of a house, traveling over land Hudson knew intimately as a child.

Hudson had arranged to ride with the children, who ranged from kindergartners to high-school seniors; spend the six-hour day at school; and accompany the children on the ride back home. In the morning, the children were too wary and shy to speak to Hudson. But in the afternoon, some of them began to pipe up, with one preteen boy telling Hudson he loved math.

The nine-hour school day (including the three hours spent idle on the bus) gave Hudson the inspiration he was searching for to help rural children, who face unique challenges in getting an education. “Many of the children live in poverty and may come from dysfunctional families. They have limited exposure to professional people,” says Hudson, a professor at the Vanderbilt University Medical Center who recently celebrated his 70th birthday. He adds that elementary and middle school teachers often don’t have the technical expertise to teach science, mathematics, technology and engineering adequately. On this point, he knew he could help.

With his wife, Julie K. Hudson, a physician and assistant vice chancellor for health affairs at the Vanderbilt University Medical Center, Billy Hudson launched the Aspirnaut Initiative in April 2006. The initiative began with an ordinary yellow school bus outfitted with laptops, iPods, and a mobile Internet router (a novelty back then) that directed the children to online STEM educational programs so they could use constructively the three hours spent each weekday on the bumpy bus ride. Now, five years later, the initiative has grown larger and involves 500 students every year.

When he started the initiative with his wife, Billy Hudson was no stranger to hard work. His scientific successes include the discoveries of two new collagen chains and a novel chemical bond that fastens them together. He received the National Institutes of Health Merit Award in 2002 and the Homer W. Smith award, the highest honor from the American Society of Nephrology, for his contributions to understanding kidney diseases in 2003.

But none of these accomplishments hints at the grueling road he took to his current position. Hudson’s “life story is fascinating,” says friend and colleague Richard W. Hanson at the Case Western Reserve University School of Medicine. “You couldn’t do more than what he has done with his life.”

From a rural gravel road to Vanderbilt 

Billy Hudson grew up on a 15-mile gravel road in rural Arkansas. “My address was Grapevine, Arkansas. The street was 40th and Plumb, meaning 40 miles from town and plumb-back in the sticks, as we’d say,” he says with a chuckle.

Billy Hudson joins a videoconference science lab beamed to a rural Maine school.

Hudson’s childhood chores in the 1940s and 1950s included tending to cotton and taking care of 20,000 chickens and other livestock. The physical labor was accompanied by regular and spurious beatings, which his father meted out with tree branches with the message that Hudson was never good enough.

Unable to stand his father’s abuse and threats of violence any more, Hudson decided at the age of 16 to drop out of high school to work on a cotton farm. His history teacher and basketball coach, Robert Theus, “knew I was going to destroy my life. He was the one who first showed me a light and how I might get out of my circumstances,” says Hudson. “There are champions who come into your life to help you. I was fortunate.”

Theus took Hudson to Henderson State Teachers College (now Henderson State University) in Arkadelphia, Ark., where Hudson was allowed to enroll without a high school diploma. There he met chemistry professor and mentor Haskell Jones, who encouraged Hudson to complete a college degree in chemistry. A cafeteria supervisor, Alice Sloan, made sure Hudson had jobs to earn room and board. After Hudson completed one year of college, his high school decided to award him an honorary diploma. Several other mentors guided Hudson into getting a Ph.D. in biochemistry at the University of Iowa under the supervision of Rex Montgomery and Robert Barker. During that time, he studied carbohydrate chemistry.

The Vietnam War was on when Hudson graduated with his Ph.D. in 1966. He joined the army and was assigned to improve filtration membranes for dialysis machines at the Army Research Institute of Environmental Medicine in Boston. It was work on the dialysis machines and a lecture by Robert Spiro of Harvard Medical School that got Hudson interested in diabetes and the havoc it wreaks on the kidneys. That interest has led to understanding the basement membranes of kidneys, which act as a filtration barrier. Diseases such as Goodpasture and Alport syndromes and renal failure arise when there are defects in the basement membrane. Hudson’s research led to the discovery of the α3 and α4 chains of collagen IV, which, along with the α5 chain, create the essential meshwork for kidney filtration. His work also has found its way into clinical applications. “Before there was such a thing as translational science, he was doing it,” notes Hanson.



A company called NephroGenex is currently developing a compound discovered in Hudson’s lab that protects against diabetic kidney disease. The U.S. Food and Drug Administration is getting close to approving a Phase III clinical trial to test the compound, Pyridorin, in more than 1,000 diabetic patients.

In 2009, Hudson and his colleagues discovered a novel sulfilimine bond, in which sulfur and nitrogen are double-bonded together, in type IV collagen. This bond exists in all animals but had not been found previously. Hudson says they have now established that an enzyme from the peroxidase family makes the unusual bond, and they think the enzyme and the sulfilimine bond emerged more than 500 million years ago as a primitive form of innate immunity.

Back to the roots to solve a problem 

Students participate in a science lab fun by the Aspirnaut Initiative.

But even with decades of scientific success under his belt, Hudson hasn’t forgotten his beginnings and has returned to rural America in hopes of helping younger generations replicate his success. “He hasn’t turned his back on people who are in the same position as he was earlier in his life,” says Hanson.

The current crisis in U.S. science, technology, engineering and mathematics education, caused by inadequate numbers of students taking an interest in these fields, could be helped if the needs of rural students were addressed, says Hudson. Twenty percent of the K – 12 student population in the United States lives in rural areas. “It’s an untapped pool of talent in rural America that can be brought into the STEM workforce,” he says. “The talent is there, but students need to be presented with opportunities.”

Aspirnaut Initiative’s first bus program rolled into something bigger within a year. Julie Hudson says it quickly became obvious that time on the school bus needed to be managed better, so the couple started an after-school class twice a week to work with the students. That class in turn grew into something else, which the Hudsons now consider to be the flagship of the initiative.

These days, researchers at Vanderbilt University hold weekly science labs via videoconference with children in rural schools. The Hudsons explain that they base the labs on those developed by the Vanderbilt Student Volunteers in Science program, which takes science kits to students attending Nashville-area schools. But with Internet-based videoconferencing capabilities, the Aspirnaut program now makes it possible to reach schools not physically near Vanderbilt. “We have a real-time interaction with the class, where we’re bringing the intellectual assets of a research university, in partnership with the school, to give students hands-on, inquiry-based, critical-thinking activities,” says Billy Hudson.

The science labs, built around real-world issues, now get beamed into classrooms in Arkansas, Tennessee and Maine. Hudson gives the example of the theme they built around his research area of diabetes. The children first learn about electricity, magnetism and the concepts of nuclear magnetic resonance spectrometry. Next, they learn about metabolism and how metabolic malfunctions cause diseases like diabetes. Then they hear about how researchers use tools like NMR spectrometry to develop therapies against a given disease. “Rather than say ‘Here’s a kit in chemistry. Good luck,’ we try to relate science and math concepts to their everyday lives through hands-on activities,” explains Hudson.

While many scientists immediately see the value of helping with K–12 STEM education, Hudson acknowledges that some say that they have pressures of their own and feel they can’t spare the time. Hudson says all that is required of a scientist is to devote an hour once in a while to show up for a videoconference with a lesson prepared for grade-school children. “We have a responsibility for educating our citizens in science,” urges Hudson. “You’re not going to turn all these teachers out there into STEM experts. You’re not going to turn the scientists into K–12 teachers. But as a partnership? It’s a winning strategy.”

Path out of poverty 

High school student Jonathan Stroud is mentored by Mohamed Rafi, Billy Hudson’s research assistant, during a summer internship. Stroud’s program mentor was Roberto Vanacore, and his research project was on Goodpasture’s syndrome.


In addition to the bus and the videoconferenced science lessons, the initiative has a third program that involves six-week summer internships for high school students doing  fundamental research in various Vanderbilt laboratories. “They come from rural communities, earn a stipend, and are provided their room and board,” explains Hudson. “We challenge them to help advance our scientific objectives.”

The students are immersed in the daily pace of research and return to high school in the fall with new experiences that inspire them to work harder in school, says Hudson. The students help the teachers organize the videoconferenced science classes and earn an hourly wage while doing so.

Out of the 36 high school students who have gone through Aspirnaut internships, 26 have finished high school, and 25 of those are now in college. (The math-loving boy Hudson met on the school bus in 2005 participated in some of the Aspirnaut programs and now is in college.)

The Hudsons visualize the Aspirnaut Initiative as a pipeline. Students first get on the school bus and start learning about science, medicine, engineering and mathematics. In elementary and middle school, they get exposed to the videoconferenced labs. Then in high school, they get hands-on experience in research laboratories and find mentors to guide them to college.

The Hudsons’ biggest wish for the initiative is for it to serve as a model for other major research universities, according to Julie Hudson. “While Vanderbilt has an enormous bandwidth, we certainly couldn’t, nor do we wish to be, the end-provider for the entire nation. We have demonstrated that the model is replicable in other rural states.”

Because of the intense mentoring that goes on with the summer interns, the Hudsons get to know the teenagers intimately. “Almost every one of these students has an incredible life story,” she says. One student was born in prison and handed off to his grandmother “in a Christmas stocking” when he was three-weeks old, recounts Hudson. The boy’s grandmother became his legal guardian. Hudson says, “They lived on almost no money for many years because all they had was her pension. That was $9,000 a year.”

Billy and Julie Hudson founded the Aspirnaut Initiative.

From a young age, the boy was very motivated to change his circumstances. He excelled in school and read a lot. In high school, he taught himself the curricula of a number of Advanced Placement courses and sat for the exams. He passed 11 AP courses eligible for college credit with flying colors. He applied to the Aspirnaut summer intern program between his junior and senior years of high school and had “an outstanding summer of research,” says Hudson. He maintained ties with Aspirnaut during his senior year of high school by helping with the bus and videoconference programs in his community. “He served as a junior mentor to the students,” she says. “He’s now a sophomore at Vanderbilt and has an excellent academic record. He’s going to apply for early decision to medical school” and is hoping to earn an M.D./Ph.D.

Students like this young man are the ones Billy Hudson always looks out for to introduce to the Aspirnaut Initiative, mindful that he broke out of the circle of poverty and abuse at the age of 16. “We show them education is a way of breaking free of difficult situations,” he states. “That’s the path I know out of poverty and out of abuse. It’s what education can do, but it can’t happen unless an opportunity passes your way.”

See past coverage of this topic in ASBMB Today.

Raj_MukhopadhyayRajendrani Mukhopadhyay ( is the senior science writer for ASBMB Today and technical editor for JBC.

I have been with the Aspirnaut Program since June 2009. At that time, I was at a point of intermission. I had been admitted to Vanderbilt University as a doctoral student and was in almost in my third year of study. There were many factors occurring that were making me think about stepping away, including the fact that I was a mother of four. During this time, a good friend of mine introduced me to Billy and mentioned that he too was interested in my passion of making science learning more accessible. I met with Billy and Julie and fell in love with the program. I became involved with the program. That was one of the best decisions of my life and I have been involved ever since with assisting with the summer science program, skyping lessons to Arkansas, and serving as a mentor to Aspirnaut students within the school year. While in this program, I spoke with Billy on many occasions and realized the importance of sticking to my goal of attaining my PhD at Vanderbilt. He mentored me and gave me an opportunity to step back into benchwork with invaluable mentorship. It would make a difference in so many lives, including my own. I would be able to mentor more students that are under-represented in science and use my story as an inspiration of continuing your goal in the face of adversity. Billy and Julie’s passion of science exposure to the underserved runs very deep and their love, inspiration, and resources for these students runs deeper. I am proud to call myself an Aspirnaut because the program has been there in so many ways for me, giving me an opportunity to build my skills and resume, and allowing me to play many roles within the program that showcase me and my love for equitable, legitimate exposure of minorities to the world of science. I am an African American mother of four who recently graduated from Vanderbilt with an Interdisciplinary Degree in Biomedical Sciences and Science Education and am ready to create ways to make scientific concepts and the thought of it equally enticing to students of all backgrounds!!
—Isi Ero-Tolliver, Ph.D.

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I am truly greatful to have had such a great experience through the Aspirnaut program.This experience helped me get through the challenges i was facing, by giving me a place to look forward to going every was my oasis and I loved every bit of it. I had fantastic mentors, and I was surrounded by great people who wantd to help me and whatch me achieve. I am truly greatful to this program for giving me the boost i needed to continue on, and giving me something to hold on to and remember. i know i will never forget the rope and the well story Dr.Hudson told me about. i learned so much and fell in love with biology all over again. Thank you once again for this amazing experience(Jessica Dix)


The Aspirnaut program changed my perspective about everything I knew about college. It gave me the confidence within to believe that I can achieve the dreams I had but thought would not come true. I know now that I am capable of anything I put my mind to. I owe a huge thanks to Drs. Billy and Julie Hudson. They are wonderful people who know just how to get involved with young people and give them an opportunity to become more knowledgeable. This was one of the best experiences of my entire life and I would not have as much knowledge as I do had I not gone. I really can not thank you more for making it possible to come to Vanderbilt and do research, it's really amazing that this had been made possible for all these kids. I am proud to be called an Aspirnaut student and hope to stay one for like. Thank you for givinge perspective and confidence this summer. I had a really great mentor and the time spent at Vanderbilt this summer was amazing. Thank you once again! -Haley Harrington


The Aspirnaut Program will probably be something I can hold on to for the rest of my life in whatever I do. As working in the Laboratory at Vanderbilt as part of this program, I have gain unprecedented knowledge that I wouldn't receive at my High School, probably not till college. Dr. Billy Hudson since day 1 of me arriving at this Internship was always supportive and reminded me I was special. Everyday I walked into the Lab with a new goal, a new responsibility, and a new set of skills that will always be with me. Now from this program I received an awesome amount of experience in a top Laboratory in the Country but most Importantly I gained new access to what I could become. Because of this program I don't know what I want to be between an Engineer, Doctor, Researcher, and a Businessman. As a Junior at Omaha High School in Omaha, Arkansas, I can only say Thank you Dr. Hudson for everything! Brennan Boone


As an undergraduate in Dr. Hudson’s lab since the summer of 2009, it is impossible for me to express enough admiration toward the Aspirnaut program. I have witnessed first-hand the difference this program has made in the lives of high school students from Arkansas. Their success as undergraduate students at Vandy is a testament to the positive influence of the program (congrats Cody on early admission to Vandy Med!). I am also forever grateful for the integral role that Aspirnaut has played in my life! As a young college student, Aspirnaut provided me with a path full of opportunity. It helped me define my interest in science, inspired me to excel academically, and provided phenomenal biomedical research experiences to prepare me for the next step in my education. Without Aspirnaut, there would be no high honors, no research awards, and no grad school at Yale. Thanks Dr. Hudson and thanks Aspirnaut for everything! -Wes Robertson


I will be forever thankful to this program. I have not only learned more than I could ever imagine but also confirmed my career goal as a medical professional. Horton.


As a college student who worked in Dr. Hudson's lab as a part of the summer program, I can say that this was truly one of the most valuable experiences I have ever had. I was surrounded by such inspirational mentors, learned fascinating science, and was able to spend time with a variety of awesome students. Thank you Dr. Hudson for your vision, and for giving so much to others. I can't wait to be back in the lab this summer! --Jillian Balser


This is a heartwarming story but shows what men and women who come from humble beginnings can do in changing the world for others. After all, making our world a better place than we found it is our reason for being.


I cannot begin to express the gratitude I have for Dr. Hudson. After participating in the Aspirnaut program, I feel much more prepared for the challenges I will face in college. It is because of the Aspirnaut Program that I have found my calling and have been given the drive to study Biochemistry and Cellular and Molecular Biology. Thank You Dr.Hudson! -Brennan Hicks



Its not only high school students that the Hudsons help. I participated in the summer Aspirnaut program as a undergraduate. It was the best experience I had in undergraduate research. I cannot fully express how thankful I was to be able to be a small part of this program. It was an enriching summer in so many ways. Thank you again. (Charli Bobbitt)


I am honored to be a cousin to Dr. Billy Hudson in more ways than one. First, I admire him for the courage he had to get his mother, sister, brother and himself away from the abusive father. Also because of the initiative he had to get an education and making a success of himself and his willingness to help today's young people to do the same. He and Julie are doing a great work in the programs for the youth. The "Gravel Road to Vanderbilt" mentioned in the article was just a dirt wagon road up until the Great Depression when the WPA upgraded it, making it suitable for modern day transportation. Times was so hard that the people planted their garden seed in the fresh dirt along the newly made road, thus giving it the name, Garden Seed Road. Yes, the area is rural Arkansas to the core and thanks to Billy & Julie for caring enough to help the young people, along this road and other roads like it, to a sussessful life. Jerry Lawrence


The work of this man is inspirational. It is point of pride to know someone who has worked with Billy. The work with kidney disease will save thousands of people from early deaths.


Awesome program! This country needs more of this kind of thinking and action. Thank you for providing a model and showing the importance of reaching out to give opportunity and guidance that makes a difference, one person at a time. Noelynn Oliver


It was Billy Hudson's course in Biochemistry at Oklahoma State University that inspired me to pursue graduate studies in Biochemistry. We've stayed in touch through the years and I'm proud to consider him both a friend and a mentor. Thank you for this article and for showing that great scientists can be great humanitarians. Bill Church


As an individual growing up and attending school from grade 1 through 12 with Billy Hudson in Grapevine, AR I am very proud of him and his work. The article is very interesting but does not give him any more credit for helping others than he deserves. I have always loved him like a brother and he will always remain my lifelong friend. Shelba Fielding Bradford



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