November 2011

Systems biology

Orion Weiner (University of California, San Francisco) will discuss signal-transduction networks in chemotaxing neutrophils and how altering cell geometries can help to identify or rule out mechanisms underlying spatial organization of the signaling components.

Victor Sourjik (Ruprecht-Karls-Universitat Heidelberg) will discuss the assembly and dynamics of signal processing complexes used by bacteria to extract and respond to weak signals from noisy environments.

Networks and noise 

The final session will focus on core design principles by which biological networks can reliably give rise to cellular behaviors despite – or because of – the presence of biochemical noise. Steve Altschuler (University of Texas Southwestern Medical Center at Dallas) will discuss how simple positive feedback circuits that lie at the heart of many pattern-forming networks can make use of biochemical noise to create cell polarity and how noise can be used as a biomarker to discriminate different mechanisms of redundancy in protein interaction networks.

Jeff Hasty (University of California, San Diego) will describe how synthetically designed biological circuits, lab-on-a-chip microfluidic devices and mathematical modeling can be brought together to understand the complexities of gene-regulatory networks in single cells.

Chris Voigt (Massachusetts Institute of Technology) will present recent work on developing a platform for designing biological networks that enable cells to be programmed to perform reliably complex, coordinated tasks.

Meetings_Systems_Biology_AltschulerMeetings_Systems_Biology_HoffmannSteven Altschuler ( is an associate professor at the University of Texas Southwestern Medical Center at Dallas. Alexander Hoffmann ( is a professor at the University of California, San Diego. 

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