Delivering the message 

Qualitative and quantitative protein output is the ultimate hallmark of cell function. Key mechanisms to control this are focused at two points: initiation of translation when the mRNA encounters the ribosome and a still-enigmatic step controlled by microRNAs. In the final session, “Ribosomes: Regulation of Access to mRNA,” we will explore these key steps.

First, Tatyana Pestova (State University of New York Downstate Medical Center) will present her work on the mechanisms of initiation of prokaryotic protein synthesis.

Although prokaryotic ribosomes have informed our understanding of eukaryotic translation, there remain important differences. Jon Lorsch (Johns Hopkins University School of Medicine) will explain how the mechanics of mRNA recruitment to the eukaryotic ribosome leads to control of initiation.

Finally, Nahum Sonenberg (McGill University) will treat us to his lab’s latest findings on the mechanism of action of miRNAs in controlling mRNA translation.

Manny Ares (ares@biology.ucsc.edu)  is a professor at the University of California, Santa Cruz, and Tracy Johnson (johnsont@ucsd.edu) is an associate professor at the University of California, San Diego.