Protein quality control and disease

The last session will highlight some of the connections between defects in protein biogenesis and associated diseases.

First, Edward Fisher (New York University) will describe how apolipoprotein B is degraded in cells, an event that is connected intimately to lipid metabolism, cholesterol transport and heart disease.

Phyllis Hanson (Washington University School of Medicine) will discuss the molecular basis for a neurological disorder that arises from a defective form of an ER-resident, chaperone-like protein.

Finally, Jason Gestwicki (University of Michigan) will discuss new approaches to identifying small-molecule modulators of chaperone action and their use in disease models.

Jeffrey L. Brodsky (jbrodsky@pitt.edu) is the Avinoff professor of biological sciences at the University of Pittsburgh, and William M. Clemons Jr.(clemons@caltech.edu) is an assistant professor of biochemistry at the California Institute of Technology.