August 2011

Anne-Claude Gingras: probing phosphatase complexes

Since that first day in Sonenberg's lab, Gingras' life certainly has been a whirlwind of activity, but 17 years, more than 80 papers, and several novel discoveries later, she still is ready for more.

"The power of modern mass spectrometers for quantification is only beginning to be tapped into by systems biologists," she says. "In interaction proteomics, for example, most large-scale studies involve static interaction maps, which reveal nothing about protein complex assembly, the stoichiometry of the subunits or the dynamics of the interactions. Over the next few years, we will see all these quantitative measures implemented into large projects both in systems biology and clinical proteomics. It's going to be fun."

"Soon, I will no longer be considered a young researcher," she adds, "but in this field I can stay young at heart for a very long time."

References

Ceccarelli, D. F., Laister, R. C., Mulligan, V. K., Kean, M. J., Goudreault, M., Scott, I., Derry, W. B., Chakrabartty, A., Gingras, A. C., and Sicheri, F. (2011) CCM3/PDCD10 heterodimerizes with GCKIII kinases using a mechanism analogous to the CCM3 homodimerization mechanism. J. Biol. Chem. May 11. [Epub ahead of print]

Kean, M. J., Ceccarelli, D., Goudreault, M., Sanches, M., Tate, S., Larsen, B., Gibson, L. C., Derry, W. B., Scott, I. C., Pelletier, L., Baillie, G. S., Sicheri, F., and Gingras, A. C. (2011) Structure-function analysis of core STRIPAK: a signalling complex implicated in golgi polarization. J. Biol. Chem. May 11. [Epub ahead of print]

Choi, H., Larsen, B., Lin, Z. Y., Breitkreutz, A., Mellacheruvu, D., Fermin, D., Qin, Z. S., Tyers, M., Gingras, A. C., and Nesvizhskii, A. I. (2011) SAINT: probabilistic scoring of affinity purification-mass spectrometry data. Nat. Methods 8, 70 – 73.

Liu, G., Zhang, J., Larsen, B., Stark, C., Breitkreutz, A., Lin, Z. Y., Breitkreutz, B. J., Ding, Y., Colwill, K., Pasculescu, A., Pawson, T., Wrana, J. L., Nesvizhskii, A. I., Raught, B., Tyers, M., and Gingras, A. C. (2010) ProHits: integrated software for mass spectrometry-based interaction proteomics. Nat. Biotechnol. 28, 1015 – 1017.

Gingras, A. C., Caballero, M., Zarske, M., Sanchez, A., Hazbun, T. R., Fields, S., Sonenberg, N., Hafen, E., Raught, B., and Aebersold, R. (2005) A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Mol. Cell. Proteomics 4, 1725 – 1740.

Gingras, A. C., Raught, B., Gygi, S. P., Niedzwiecka, A., Miron, M., Burley, S. K., Polakiewicz, R. D., Wyslouch-Cieszynska, A., Aebersold, R., and Sonenberg, N. (2001) Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev. 15, 2852 – 2864.

Nick Zagorski (nicozags@gmail.com) is a freelance science writer.

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Anne-Claude is a human dynamo! Great article on a great researcher and colleague! Jim Woodgett

 

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