The October issue continues our "Defying stereotypes" series of articles about people who were trained in science but who have made their names in other ways. In this issue, we feature Craig Breslow, a brainy baseball player who worked under scientist Joan Steitz at Yale University. We also have a feature on Michael Weiss at Case Western Reserve University, whose company, Thermalin Diabetes, is gearing up to do human trials of an ultraconcentrated, rapid-acting insulin analog. In our perspectives section, Bob Eisenberg of Rush University Medical Center asks, "Shouldn't we make biochemistry an exact science?" And we're proud to report that two ASBMB members won the 2014 Lasker award for their work on the unfolded protein response. We hope you will enjoy — and share — the October issue!