MOLECULAR MECHANISMS OF CELL SIGNALING

Breakthroughs in sending the message

Published September 01 2019

Talks

  • Piezo1 gains traction — Medha Pathak, University of California, Irvine
  • Mechanotransduction in vascular health and disease — Martin Schwartz, Yale University
  • Mechanical force and Notch signaling — Wendy Gordon, University of Minnesota
  • Mechanisms linking mechanotransduction and cell metabolism — Kristin DiMali, University of Iowa
  • Getting hedgehogs where they need to go — Stacey Ogden, St. Jude Children’s Research Hospital
  • Rhomboid proteins in cell signaling — Matthew Freeman, University of Oxford
  • Lipids and hedgehogs — Adrian Salic, Harvard Medical School
  • Role of Notch glycosylation in signaling — Pamela Stanley, Albert Einstein College of Medicine
  • Ligand engineering for probing receptor signaling mechanisms — Chris Garcia, Stanford University
  • Cellular communication via adhesion — Demet Arac, University of Chicago
  • Mechanisms of Wnt5a-Ror signaling in development and disease — Henry Ho, University of California, Davis
  • Wnt/planar cell polarity signaling in skeletal development — Yingzi Yang, Harvard Dental School

Some of the most fascinating biological processes, such as embryonic development, tissue regeneration and the physiological integration of body functions, rely on a network of cell–cell communication pathways.

Although the molecular players in cell–cell communication have long been known from genetic studies in model systems, many of the underlying mechanisms only now are beginning to be deciphered. Within this area, cell-surface receptors function like air-traffic controllers, integrating inputs from the cell’s exterior and interior to trigger signal transduction pathways, leading to specific cellular responses.

This session will focus on emerging mechanisms in cell-cell communication, particularly how cell-surface receptors interpret mechanical stimuli, how signaling molecules are controlled by less well understood post-translational modifications and how signaling polarizes cells and tissues. The session will showcase diverse modern approaches to understanding cell signaling, ranging from structural to organismal biology.

Keywords: mechanobiology, structural biology, post-translational modifications, signal transduction, receptors, ligands.

Who should attend: cell biologists, biochemists, structural biologists and developmental biologists, and particularly grad students and postdocs interested in emerging themes and state-of-the-art methodology in cell–cell signaling research.

Theme song: “Hotel California” by the Eagles. Once you come to our session, you will not want to leave.

This session is powered by communication.

Wendy Gordon Wendy Gordon is an assistant professor of biochemistry at the University of Minnesota specializing in mechanobiology. Follow her on Twitter

Adrian Salic Adrian Salic is a professor of cell biology at Harvard Medical School focusing on the biochemistry and cell biology of cell-cell signaling. Follow him on Twitter