Zhu wins Tabor award
for novel proteomic approach

Published January 05 2016


Haojie Zhu, assistant professor in the department of clinical pharmacy at the University of Michigan, was named the recipient of a Journal of Biological Chemistry/Herbert Tabor Young Investigator Award for his work on a novel approach for precise quantification of drug-metabolizing enzymes and transporters. This pharmacoproteomics assay has been used to identify and characterize the variants that regulate gene expression at a protein level. Zhu’s work has the potential to provide essential information for effectively guiding personalized medicine. The JBC’s deputy editor, Fred Guengerich of Vanderbilt University, presented the Tabor award to Zhu at the 21st International Symposium on Microsomes and Drug Oxidation in early October in Davis, California.

“My laboratory has developed a novel pharmacoproteomics approach combining pharmacogenomics and proteomics for identification and characterization of genetic and non-genetic biomarkers that are associated with individual variability in drug response,” says Zhu. He adds that these biomarkers eventually can be used in clinical practice to improve the efficacy and safety of pharmacotherapy. A better understanding of individual variability in the function of drug-metabolizing enzymes and transporters will help clinicians develop more personalized therapeutic regimens to improve outcomes for their patients.

Zhu was born and raised in Yangzhou, a city in east China. He received a pharmacy diploma from the China Pharmaceutical University and returned to the same university several years later for graduate school. After completing his Ph.D. in pharmacology, he joined the laboratory of C. Lindsay DeVane and John Markowitz at the Medical University of South Carolina, where he conducted his postdoctoral research in pharmacogenomics and neuropharmacology. After his postdoctoral training, he continued his research in translational pharmacogenomics as a research assistant professor, first at MUSC and then at the Center for Pharmacogenomics at the University of Florida College of Pharmacy. Zhu joined the University of Michigan in 2013.

Lee D. Gibbs Lee D. Gibbs is a Ph.D. candidate at the University of North Texas Health Science in the department of molecular and medical genetics.