JBC: Implicating proteins in synaptic plasticity


The Journal of Biological Chemistry recently published a collection of thematic minireviews edited by Roger J. Colbran of Vanderbilt University. Titled “Molecular Mechanisms of Synaptic Plasticity,” the series includes four reviews that discuss recent advances in understanding the mechanisms that modulate synaptic protein production and function as well as the effects of these mechanisms on synaptic plasticity.

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JBC: 'I was surprised we even got the paper accepted'


At first, no one took them seriously. In 1991, Rafael Radi, Joseph Beckman, Kenneth Bush and Bruce Freeman published a paper in the Journal of Biological Chemistry demonstrating that a molecule called peroxynitrite, the product of a reaction between nitric oxide and superoxide radicals, selectively attacked sulfhydryls in proteins. Beckman recalls: “It was considered an unproven theory. I was surprised we even got the paper accepted in JBC.” Today, the paper is recognized as a JBC Classic. It has been cited more than 2,100 times.

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JLR: Witztum steps down as co-editor


Joseph L. Witztum has stepped down as co-editor-in-chief of the Journal of Lipid Research. Witztum joined the JLR editorial board leadership as deputy editor in 2003. In 2008 he was named co-editor-in-chief alongside Edward A. Dennis. JLR Associate Editor William L. Smith of the University of Michigan was named Witztum's replacement as co-editor-in-chief.  

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JBC: The details of DNA end resection


The most common repair mechanism for double-stranded DNA breaks is nonhomologous end joining, which reattaches broken DNA strands with minimal processing and without regard to missing nucleotides. The other repair mechanism, which is less error-prone, is homologous recombination, in which a single-strand overhang invades a similar or identical strand from a sister chromatid and uses it as a template to repair breaks. This repair process is the focus of a recent minireview published in the Journal of Biological Chemistry.

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