Paul wins Tabor award
for Huntington's work

Bindu Paul won the Tabor Award in May at the third European Conference on the Biology of Hydrogen Sulfide. JBC associate editor Ruma Banerjee issued the award.

Bindu Paul, a neuroscience instructor at Johns Hopkins University, received the Journal of Biological Chemistry/Herbert Tabor Young Investigator Award for her ongoing research into the role of cysteine and its derivatives in Huntington’s disease.

Paul works on understanding regulatory mechanisms present in neurodegenerative diseases in the laboratory of Soloman H. Snyder at Johns Hopkins. Since joining the lab, she has discovered a depletion of the biosynthetic enzyme for cysteine, which mediates disease progression in Huntington’s. Now Paul is looking at the role of cysteine and hydrogen sulfide. She is interested in how the interaction of hydrogen sulfide with other gasotransmitters like nitric oxide and carbon monoxide affects regulation of both neuroprotective and neurodegenerative states.

Paul is hopeful about the applications of this new research. “Understanding the interplay of these three messenger molecules would pave the way to develop novel therapeutics in diseases involving dysregulated gasotransmitter signaling,” she says.

Paul grew up in India and received her Ph.D. from the Indian Institute of Science in Bangalore. Her graduate work focused on transcriptional regulation and DNA-binding proteins. Paul went on to postdoctoral studies at the National Institutes of Health in the laboratory of Yun-Bo Shi. There she studied the tissue-specific effects of thyroid hormone and used her expertise in transcriptional studies to understand better the gene regulatory pathways affected by the hormone.

Bree Yanagisawa Bree Yanagisawa is a graduate student at the Johns Hopkins School of Medicine and managing editor of the Biomedical Odyssey blog.