Special symposium:
membrane-anchored serine proteases

Join us at this small, focused meeting in September in Maryland

The unveiling of a new family of serine proteases that are anchored directly to the plasma membrane was an unexpected outcome of the complete sequencing of several vertebrate genomes at the turn of the millennium. The American Society for Biochemistry and Molecular Biology will host a special symposium this fall focusing on the biochemistry, biology and pathophysiological functions of membrane-anchored serine proteases, including the translational research opportunities afforded by this interesting group of enzymes.

Recent studies have revealed that the membrane-anchored serine proteases are important components of the mammalian degradome, playing critical roles in both health and disease through the regulation of metabolic homeostasis, fertilization, morphogenesis, epithelial biology, iron homeostasis, cardiovascular diseases, viral infection and cancer.

The main objectives of the symposium in September will be to bring together leading scientists to present their latest research on all aspects of this new, highly active and rapidly expanding area of research; to enhance the dissemination of the latest progress; and to accelerate the generation of new knowledge. Particular emphasis will be given to presentations of new insights into basic molecular and biological mechanisms and to translational research efforts.

The meeting also will be a venue for junior researchers at the graduate and postdoctoral levels to discuss their research and forge scientific connections, including collaborations.

Speakers will include both renowned, established investigators in the field and up-and-coming researchers. To encourage participation of a wide range of scientists, the majority of the speakers will be selected from submitted abstracts. We encourage researchers from academic institutions, government and industry to attend.

About the meeting

When: Sept. 17 — 20

Where: Potomac, Md.

Sampling of speakers:

  • Eva Böttcher-Friebertshäuser has provided key insights into the roles of host proteases in regulating viral pathogenicity. Her laboratory discovered that infection and dissemination of influenza virus is dependent on cleavage activation of influenza virus hemagglutinin by the host transmembrane serine proteases TMPRSS2 and HAT in the human airway epithelium.
  • Thomas Kleyman, a longtime investigator of epithelial Na+ channels, has made key contributions to understanding the molecular structure of the channel’s pore and the key roles of Na+, divalent metal ions and membrane serine proteases in the regulation of channel activities.
  • Qingyu Wu is a longstanding investigator of corin, a membrane serine protease essential for natriuretic peptide processing and whose depletion is associated with hypertension, heart disease, preeclampsia and chronic kidney disease. His laboratory has made key contributions to the structure, function and genetics of corin and its roles in disease.
  • Charles Craik is a pioneer in structure-function studies of proteases and their inhibitors using a combination of genetic, biochemical and biophysical methods. His emphasis is on identifying the roles and regulation of the activities of membrane-anchored serine proteases associated with infectious diseases, cancer and development.
  • Jan K. Jensen is a structural biologist whose work has provided new insight into the structure and function of hepatocyte growth factor activator inhibitor, or HAI, domains, the proteins that act as cofactors for many of the type-2 transmembrane serine proteases.

Deadlines:

  • June 11: Deadline to submit abstract for oral presentation consideration
  • June 18: Deadline for discounted registration (save $100)
  • July 15: Deadline to submit abstract for poster presentation
Karin List Karin List studies the role of type II transmembrane serine proteases and their inhibitors in cancer progression at Wayne State University School of Medicine.




Toni Antalis Toni Antalis studies the physiological roles of membrane-anchored serine proteases at the University of Maryland School of Medicine.