DNA replication and repair

Cellular systems for repair

DNA replication and repair
In their 1953 paper describing the structure of B-DNA, Francis Crick and James D. Watson recognized that noncanonical base pairs could be sources of mutations. As most mutations are deleterious, the repair of aberrant DNA structures is an essential cellular process. More recently, a vibrant field of research has grown around the discovery and characterization of cellular systems that repair or accommodate noncanonical base pairs. This ASBMB annual meeting symposium on DNA replication and repair will provide a present-day overview of important parts of these systems and the mechanisms by which they operate.
 
The first session will give a perspective on structural and biochemical mechanisms of aberrant translesion DNA replication.
 
Structural insights into replication fidelity and mismatch repair will be explored in the second session, as will super-resolution live cell-imaging studies that track the movements of individual proteins involved in replication, repair and recombination.
 
The third session will explore the range of DNA topologies present in repair complexes and the adaptations that allow repair processes to accommodate them.
 
Replication and repair complexes often contain many components that interact, sometimes over large physical distances. The fourth session will explore the roles of cooperativity in the function and regulation of these complexes.
Michael G. Fried   Myron F. Goodman  
Organizers: Michael G. Fried, University of Kentucky College of Medicine, and Myron F. Goodman, University of Southern California