Thematic series on phospholipase D and cancer


A new thematic minireview series in the Journal of Biological Chemistry focuses on phospholipase D and its role in cancer. PLD signaling controls a variety of cellular activities (namely, proliferation, migration and lipid metabolism) and thus plays a key role in cancer invasion and metastasis. The series highlights PLD’s tumorigenic potential, tools to study its in-vivo function, its putative role in inflammatory diseases, and regulation of levels of the signaling metabolite, phosphatidic acid. A deeper understanding of PLD has broad applications in developing targeted drug therapies for cancer.

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Thematic series on prions


More than 30 years ago, Stanley Prusiner at the University of California, San Francisco, coined the term “prion” and began to develop evidence to support his radical hypothesis for a new kind of infectious agent. Since then, the prion hypothesis – that scrapie, a fatal neurodegenerative disease in sheep and goats, is caused by a misfolded protein devoid of a genomic component – has been proved. The new dogma that resulted has been fruitful for guiding new approaches to studying Alzheimer’s and Parkinson’s diseases. In addition, emerging biochemical details of the pathogenesis of misfolded proteins are beginning to provide potential targets for therapy.In a new thematic minireview series in the Journal of Biological Chemistry, Prusiner and other researchers cover prion replication, transmission and neurotoxicity.

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How a squid forms a relationship with a bacterium


How do you get into a mutually beneficial relationship? That is the question researchers asked in a recent paper in the journal Molecular & Cellular Proteomics, albeit for a squid and its bacterial partner. The researchers showed that in order for the Hawaiian bobtail squid to form a symbiotic relationship with the bioluminescent Vibrio fischeri, proteomic changes have to occur in a set of cells of the squid.

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Thematic series on caloric restriction and ketogenic diets


The September issue of the Journal of Lipid Research marks the beginning of a new thematic review series examining how diet modifications improve general health and manage a broad range of chronic diseases.

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