Translating the biophysics of molecular switches

Signaling mechanisms and inhibition of Ras and Rho GTPases

Photo courtesy of the Virginia Tourism Corporation

Translating the Biophysics of Molecular Switches: Signaling Mechanisms and Inhibition of Ras and Rho GTPases
July 17 – 20
Location: Wyndham Virginia Crossings, Glen Allen, Va.
Organizers: Matthias Buck, Case Western Reserve University; Sharon Campbell, University of North Carolina; Alemayehu Gorfe, University of Texas Medical School at Houston

Matthias Buck Sharon Campbell Alemayehu Gorfe
Buck Campbell Gorfe

Early registration and abstract submission deadline:
April 16

It is a particularly exciting time for studies of small Ras and Rho GTPases! Finally, after decades of cloudy skies, bright spots are emerging as the drugability of these critical molecular switches now appears promising.
Furthermore, building upon structural, biochemical and biological exploration, new mechanisms have been discovered involving these GTPases — specifically, the role of phosphorylation, ubiquitination, intra‐ and inter‐protein allostery, and new effector and regulatory protein interactions.
This special symposium will provide a platform for the discussion of front-line research in these and other key areas. The symposium will cover a range of topics, including the application of biophysical and computational methods that have reshaped significantly our understanding of Ras and Rho GTPases, elucidation of new regulatory mechanisms, and deciphering complex signaling pathways and feedback loops.
Through these advances, new therapeutic strategies to target small GTPases are emerging, as highlighted in the sessions. The conference will start with a special session for young investigators with a discussion on topics important for career development. Half of the presentations will be chosen from abstracts with a preference for graduate students, postdocs and young investigators. Poster sessions, meals and a reception will provide opportunities for extensive interactions.

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