Potential target in allergic responses


In a recent issue of The Journal of Biological Chemistry, scientists at the Northwestern University Feinberg School of Medicine showed that IRE1α also promotes the production of cytokine IL-4, a key regulator in adaptive immunity. Among its effects in the immune system is the stimulation of B cells to produce IgE, an immunoglobulin associated with allergies.

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Structure-specific tear lipid changes in dry-eye syndrome


Two papers in the Journal of Lipid Research give dry-eye syndrome a closer look.

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