Program

 

 

Thursday, Oct. 4  
   
5:00 pm -6:15 pm Dinner - Golden Cliff
   
6:30 pm -6:45 pm Welcome and Opening Remarks by the Organizers - BALLROOM
   
6:45 pm -7:30 pm Keynote Lecture:
  Cryo-EM for the Characterization of Structure and Dynamics of Complexes Involved in Transcriptional Regulation
  Eva Nogales, University of California, Berkeley
   
7:30 pm -8:50 pm Session I: Transcription Regulation by Non-coding RNA
   
7:30 pm - 7:50 pm High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue-specificity 
  John Rinn, University of Colorado
7:50 pm - 8:05 pm Noncoding RNAs Coordinate with Histone Acetylation to Regulate the Binding and Transcriptional Functions of Chromatin Reader Proteins
  Shannon Lauberth, University of California, San Diego
8:05 pm - 8:25 pm Fetal γ-globin genes are regulated by the BGLT3 long non-coding  RNA locus
  Ann Dean, National Institutes of Health
8:25 pm - 8:45 pm RNA polymerase II modeling predicts the activity of transcription factors
  Robin Dowell, University of Colorado 
   
9:00 pm - 11:00 pm  Welcome Networking Reception - Golden Cliff
   
Friday, Oct. 5   
   
7:00 am - 8:15 am  Breakfast - Golden Cliff
   
8:30 am - 10:25 am  Session II: Transcription Factors - BALLROOM 
   
8:30 am - 8:50 am DNA Binding Bispecificity by Forkhead Transcription Factors [6]
  Martha Bulyk, Harvard University
8:50 am - 9:05 am Evidence of restricted pioneering activity in vivo during human embryonic stem cell differentiation [7]
  Michael Meers, Fred Hutchinson Cancer Research Center
9:05 am - 9:25 am Overcoming chromatin barriers to change cell fate [8]
  Ken Zaret, University of Pennsylvania
9:25 am - 9:40 am Mechanisms specific to ETS family transcription factors that promote prostate cancer [9]
  Peter Hollenhorst, Indiana University
9:40 am - 10:00 am Designing Synthetic Transcription Factors that function as "pause release" buttons [10]
  Aseem Ansari, University of Wisconsin-Madison
10:00 am - 10:20 am Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators [11]
  Anna Mapp, University of Michigan
10:20 am- 10:55 am Networking Coffee Break
   
10:55 am -12:30 pm Session III: Transcription Initiation
   
10:55 am - 11:15 am Structural insight into transcription initiation by RNA polymerase I and III [12]
  Christoph Müller, European Molecular Biology Laboratory
11:15 am - 11:35 am  Transcription Activation Mechanisms and Coactivator Function [13]
  Steven Hahn, Fred Hutchinson Cancer Research Center
11:35 am - 11:55 am Understanding transcription regulation through kinase inhibition and biochemical reconstitution [14]
  Dylan Taatjes, University of Colorado
11:55 am - 12:10 pm KAP1 Couples RNA Polymerase II Transcription Initiation and Elongation [15]
  Ivan D'Orso, The University of Texas Southwestern Medical Center
12:10 pm - 12:30 pm Imaging transcription initiation and chromatin remodeling factors at single-molecule resolution in living yeast [16]
  Carl Wu, Johns Hopkins University
   
12:30 pm - 1:45 pm Lunch - Golden Cliff
   
2:00 pm -3:35 pm   Session IV: RNA Polymerase II - Ballroom
   
2:00 pm - 2:20 pm Mechanisms of RNA Polymerase II transcription [17]
  Craig Kaplan, Texas A&M University
2:20 pm - 2:35 pm Pause and go: structural basis for mammalian RNA polymerase II elongation control [18]
  Lucas Farnung, Max-Planck-Institute, Göttingen, Germany 
2:35 pm - 2:55 pm Molecular basis of transcription and DNA repair: lesion recognition, blockage, bypass, and repair [19]
  Dong Wang, University of California San Diego
2:55 pm - 3:10 pm The capping enzyme facilitates the transition from transcription initiation to elongation [20]
  Kenji Murakami, University of Pennsylvania
3:10 pm - 3:30 pm A novel role for Ccr4-Not in clearing arrested RNA Polymerase II from genes [21]
  Joseph Reese, Penn State University 
   
3:30 pm - 4:05 pm  Networking Coffee Break
   
4:05 pm -5:40 pm Session V: Transcription elongation I
   
4:05 pm - 4:25 pm Decipher the Combinatorial CTD Code for Eukaryotic Transcription [22]
  Jessie Zhang, University of Texas, Austin
4:25 pm - 4:40 pm Recruitment of Spt6 to RNA polymerase II linker at sites of transcription by a novel SH2-double phosphorylation mechanism [23]  
  Christopher Hill, University of Utah 
4:40 pm - 5:00 pm DisCo network analysis of RNA Polymerase II elongation and termination [24]
  Amber Mosley, Indiana University 
5:00 pm - 5:15 pm  The Role of the RSC Complex and Histone Acetylation in Regulating Chromatin Structure and Transcription Genome-Wide in Saccharomyces cerevisiae [25]
  Chhabi Govind, Oakland University, Department of Biological Sciences
5:15 pm - 5:35 pm Genomic mechanisms of gene regulation and chromatin organization [26]
  Frank Pugh, Penn State University
   
6:30 pm - 7:45 pm Dinner - Golden Cliff
   
8:00 pm - 11:00 pm Poster Session I and Networking Reception - Ballroom 
   
Saturday, Oct. 6   
   
7:00 am - 8:15 am Breakfast - Golden Cliff  
   
8:30 am - 10:20 am Session VI: Genome Architecture and Regulatory Elements - Ballroom
   
8:30 am - 8:50 am Recruitment of Polycomb group proteins in Drosophila [27]
  Judith Kassis, National Institutes of Health 
8:50 am - 9:05 am Chromatin- and Mediator-dependent epigenetic transcriptional poising [28]
  Jason Brickner, Northwestern University 
9:05 am - 9:25 am Mediator is essential for small nuclear and nucleolar RNA transcription in yeast [29]
  Gabriel Zentner, Indiana University
9:25 am - 9:40 am Targeted enhancer activation by a subunit of the Integrator complex [30]
  Alessandro Gardini, The Wistar Institute 
9:40 am - 10:00 am Regulation of transcriptional states by nuclear pore proteins [31]
  Maya Capelson, University of Pennsylvania 
10:00 am - 10:15 am Enhancer deregulation in acute leukemia [32]
  Yali Dou, University of Michigan
   
10:20 am - 10:50 am Networking Coffee Break  
   
10:50 am - 12:25 pm Session VII: Structure and function of chromatin-associated factors 1 
   
10:50 am - 11:10 am Histone H2B deubiquitination and nucleosome dynamics [33]
  Cynthia Wolberger, Johns Hopkins University
11:10 am - 11:25 am Cryo-EM structure of a minimal RSC remodeling complex bound to a nucleosome [34]
  Andres Leschziner, University of California, San Diego
11:25 am - 11:45 am Nucleosome assembly in transcription and replication [35]
  Karolin Luger, University of Colorado 
11:45 am - 12:00 pm Structure and function of the chromatin remodeling enzyme ISWI [36]
  Felix Mueller-Planitz, Ludwig-Maximilians-Universität, Munich
12:00 pm - 12:20 pm Nucleosome sliding by the Chd1 remodeler [37]
  Gregory Bowman, Johns Hopkins University
   
12:30 pm - 6:30 pm Lunch and Free Time
   
6:30 pm - 7:45 pm Dinner - Golden Cliff
   
8:00 pm - 11:00 pm Poster Session II and Networking Reception - Ballroom
   
Sunday, Oct. 7  
   
7:00 am - 8:15 am Breakfast - Golden Cliff
   
8:30 am - 10:05 am Session VIII: Co-transcriptional Processes - Ballroom
   
8:30 am - 8:50 am Nascent RNA and the coordination of splicing with transcription [38]
  Karla Neugebauer, Yale University
8:50 am - 9:05 am The influence of ELL2, an inducible transcription elongation factor, on RNA splicing [39]
  Christine Milcarek, University of Pittsburgh
9:05 am - 9:25 am  Spt6 association with RNAPII directs mRNA turnover during transcription [40]
  Brian Strahl, University of North Carolina-Chapel Hill
9:25 am - 9:40 am The Integrator complex cleaves nascent mRNAs to attenuate transcription [41]
  Deirdre Tatomer, University of Pennsylvania
9:40 am - 10:00 am Identification of histone mutants that impair transcription termination [42]
  Karen Arndt, University of Pittsburgh
   
10:05 am - 10:40 am  Networking Coffee Break
   
10:40 am - 12:20 pm Session IX: Transcription regulation and Post-translational MOdifications
   
10:40 am - 11:00 am Role of H3K36 Methylation in Chromatin and Cancer Regulation [43]
  Or Gozani, Stanford University
11:00 am - 11:15 am  The effect of nucleosome conformation on reader domain recognition of modified histone tails [44]
  Catherine Musselman, University of Iowa 
11:15 am - 11:35 am Transcription and chromatin control by ubiquitin specific protease 7 (USP7) in development and disease [45]
  Peter Verrijzer, Erasmus University Medical Center
11:35 am - 11:50 am Examining the roles of H3K4 methylation states with systematically characterized antibodies [46]
  Michael-Christopher Keogh, EpiCypher
11:50 am - 12:10 pm Receptor-specific regulation of Cdk9 in cardiomyocyte hypertrophy [47]
  Jason Tanny, McGill University
   
12:30 pm - 1:45 pm  Lunch - Golden Cliff
   
2:00 pm - 3:35 pm Session X: Chromatin Structure and Dynamics I - Ballroom
   
2:00 pm - 2:20 pm The role of the histone chaperone FACT in transcription-independent establishment of the architecture of chromatin [48]
  Tim Formosa, University of Utah School of Medicine 
2:20 pm - 2:35 pm H3.3 phosphorylation promotes enhancer acetylation and lineage specification [49]
  Laura Banaszynski, UT Southwestern Medical Center 
2:35 pm - 2:55 pm NDF, a nucleosome destabilizing factor that facilitates transcription in chromatin [50]
  James Kadonaga, University of California, San Diego
2:55 pm - 3:10 pm Nucleosome dynamics mediated by Nap1 facilitates transcription elongation [51]
  Tae-Hee Lee, The Pennsylvania State University
3:10 pm - 3:30 pm  FACT and Spt6 Prevent the Scrambling of Histone Modifications during Transcription [52]
  François Robert, Institut de Recherches Cliniques de Montréal 
   
3:35 pm - 3:55 pm Networking Coffee Break  
   
3:55 pm - 5:30 pm Session XI: Chromatin Structure and Dynamics II
   
3:55 pm - 4:15 pm  Chemically Induced Chromosomal Interaction (CICI): A New Tool to Study Chromosome Dynamics and Its Biological Roles [53]
  Lu Bai, Penn State University
4:15 pm - 4:30 pm Molecular mechanisms of transcriptional repression by heterochromatin [54]
  Aaron Johnson, University of Colorado, Denver School of Medicine 
4:30 pm - 4:50 pm Structure and Function of Mammalian SWI/SNF Complexes in Human Disease [55]
  Nazar Mashtilar, Dana Farber Cancer Institute, Harvard Medical School
4:50 pm - 5:05 pm Super-resolution chromatin tracing reveals chromatin domains and cooperative high-order interactions in single cells [56]
  Alistair Boettiger, Stanford University
5:05 pm - 5:25 pm  Intrinsic dynamics of an endogenous human gene reveal the basis of expression heterogeneity [57]
  Daniel Larson, National Institutes of Health
   
5:30 pm - 6:45 pm   Dinner - Golden Cliff
   
7:00 pm - 7:10 pm Poster Prize Winners Announced - Ballroom
   
7:10 pm - 7:45 pm  Poster Prize Oral Presentations
   
7:45 pm - 8:45 pm Session XII: Transcription Elongation II  
   
7:45 pm - 8:00 pm Gcn4 binding within coding regions can activate both internal and canonical 5’ promoters in yeast [58]
  Alan Hinnebusch, National Institutes of Health
8:00 pm - 8:20 pm Heptad repeat-specific function and modification of the carboxy-terminaldomain (CTD) of RNA polymerase II [59]
  Dirk Eick, Helmholtz Center Munich, Munich, Germany
8:20 pm - 8:40 pm  Control of transcription elongation rate by pausing and backtracking [60]
  David Bentley, University of Colorado, Denver School of Medicine 
   
8:45 pm    Closing Remarks by the Organizers
   
9:00 pm - 12:00 am Closing Networking Reception - Golden Cliff
   
Monday, Oct. 8   Departures 
   
6:00 am - 8:00 am   Grab and go breakfast, Lobby
   
11:00 am     Check out by 11:00 am