• SpecSymp3


In addition to invited presentations, a number of speakers will be selected from submitted abstracts.  The meeting also features two Poster Sessions with poster prizes for best poster presentations.

Each session will be Chaired by a Senior Co-chair and a Postdoc or Graduate Student Junior Co-chair, who will be selected on the basis of submitted abstracts.  We encourage junior investigators, graduate students and postdoctoral fellows, especially minorities, female investigators and persons with disabilities, to attend.

The symposium will provide an excellent opportunity for investigators in this rapidly expanding field to get together to discuss the latest findings on structural, biochemical, biological, and pathophysiological aspects of membrane-anchored serine proteases.

THURSDAY, SEPTEMBER 14  Click here to view the complete program schedule.
4:00 pm – 7:30 pm Arrivals and meeting check-in
5:30 pm – 7:15 pm Dinner
7:30 pm – 7:40 pm Welcome Remarks
7:40 pm – 8:40 pm   Keynote Lecture  
  Toni Antalis, Univ of Maryland, Sch of Med, Baltimore, USA
Novel insights into the role of the membrane-anchored serine protease testisin: From angiogenesis to ovarian cancer
8:40 pm-10:30 pm Welcome Networking Reception
7:30 am-8:45 am Breakfast
(Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room)
9:00 am – 12:05 pm   Session 1:  Membrane-Anchored Serine Proteases:Structure, Specificity and Regulation  
  Co-discussion Leaders: Karin List and Signe Thomsen
9:00 am-9:30 am Charles Craik, UCSF, San Francisco, USA
Targeting dynamic protein targets for structural and functional insight
9:30 am-10:00 am Roman Szabo, NIH, Bethesda, USA
Matriptase and prostasin – not your typical proteolytic cascade
10:00 am-10:30 am John Hooper, Mater Research Inst, Univ of Queensland, Australia
Understanding the biology of a protease activated cellular receptor reveals potential avenues for targeting disseminated cancer
10:30 am-10:45 am Coffee break
10:45 am-11:05 am Karl Chai, Univ of Central Florida College of Medicine, USA
What does matriptase not cut?
11:05 am-11:25 am Hannah Limburg, Inst of Virology, Univ of Marburg, Germany
The protease specificity of influenza A virus hemagglutinin monobasic cleavage site in human and murine airway epithelial cells
11:25 am-11:45 am Sébastien Dion, Univ Sherbrooke, Canada
Transcriptome analysis of human livers and cell lines reveals expression of TMPRSS6 isoforms and mutants with altered activity
11:45 am-12:05 pm Can Wang, Soochow Univ, Suzhou, China
Transcriptional regulation of corin expression in the pregnant uterus
12:05 pm-1:30 pm &
1:30 pm-2:15 pm
Lunch &
Free time for networking
2:30 am-4:00 pm   Session 2:  Membrane-Anchored Serine Proteases: Biosynthesis, Trafficking and Cellular Mechanisms  
  Co-discussion Leaders: Roman Szabo and Hao Wang
2:30 pm-3:00 pm Chen-Yong Lin, Georgetown Univ, Washington DC, USA
Matriptase life cycle features three distinct peptide bond cleavages
3:00 pm-3:20 pm Annika Nonboe, Univ of Copenhagen, Denmark
HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase
3:20 pm-3:40 pm Dongeun Park, Seoul National Univ, Seoul, South Korea
JNK inhibitor-induced ectodomain shedding of Prss14/epithin is mediated by PKCβII and TACE translocation to the membrane
3:40 pm-4:00 pm Moon Kim, Inha Univ, Incheon, South Korea
Epithin/Prss14 intercellular domain released by the regulated intramembrane proteolysis is a transcriptional regulator of cell migration and invasion
4:00 pm-4:15 pm Coffee break
4:15 pm-6:05 pm   Session 3: Membrane-Anchored Serine Proteases in Development and Physiology  
  Co-discussion Leaders: Kiroaki Kataoka and Stine Friis
4:15 pm-4:45 pm Shaun Coughlin, UCSF, San Francisco, USA
Roles of Protease-Activated Receptor-2 activity in Zebrafish skin–– a model epithelial tissue
4:45 pm-5:15 pm Eric Camerer, INSERM, Paris, France
PAR2 signaling by membrane-anchored serine proteases: mechanisms of engagement and developmental consequences
5:15 pm-5:45 pm Edith Hummler, Univ of Lausanne, Switzerland
Regulation of ENaC by channel-activating proteases
5:45 pm-6:05 pm Ce Zhang, Soochow Univ, Suzhou, China
Molecular studies of corin expression in the apical membrane of polarized renal epithelial cells
6:05 pm-7:15 pm Dinner
7:30 pm-10:00 pm Poster Session and Reception
7:30 am – 8:45 am Breakfast
 (Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room)
9:00 am-12:15 pm   Session 4:  Membrane-Anchored Serine Proteases in Metabolism and Homeostasis  
  Co-discussion Leaders: Shaun Coughlin and Koji Yamamoto
9:00 am-9:30 am Delphine Meynard, INSERM, Toulouse, France
Matriptase-2: master regulator of iron homeostasis
9:30 am-9:50 am An-Sheng Zhang, Oregon Health & Science Univ, Portland, USA
Matriptase-2 cleaves multiple components of the hepcidin induction pathway to suppress hepcidin expression
9:50 am-10:10 am Hiroaki Kataoka, Faculty of Medicine, Univ of Miyazaki, Japan
HAI-2 is essential for the maintenance of intestinal epithelium in mice
10:10 am-10:30 am Chuan-Jin Wu, National Cancer Institute, NIH, Bethesda, USA
HAI-2, Matriptase, EpCAM and Claudin-7 coordinately regulate intestinal epithelial homeostasis
10:30 am-10.45 am Coffee break
10:45 am-11:15 am Thomas R. Kleyman, Univ of Pittsburg. USA
Proteases and epithelial sodium channels: Translating basic findings to the bedside
11:15 am-11:35 am Stine Friis, NIH, USA and Univ of Copenhagen, Denmark
Matriptase zymogen supports epithelial development, homeostasis and regeneration
11:35 am-11:55 am Jehng-Kang Wang, National Defense Medical Center, Taipei, Taiwan
Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death
11:55 am-12:15 pm Robert A. Lazarus, Genentech, Inc.
Mechanism of Allosteric Activation of Tryptase: Dual Functionality of Tryptase Protomers as Both Proteases and Cofactors
12:15 pm – 1:45 pm Lunch and networking
2:00 pm-5:10 pm   Session 5:  Membrane-Anchored Serine Proteases in Cancer and Host Defense  
  Co-discussion Leaders: Charles Craik and Gregory Conway
2:00 pm-2:30 pm James Janetka, Washington Univ, St. Louis, USA
Resistance to anticancer therapy derived from serine protease activation of growth factors
2:30 pm-2:50 pm Gregory Conway, Univ of Maryland, Baltimore, USA
Expression of testisin reduces ovarian tumor metastasis through a PAR-2-angiopoietin signaling pathway
2:50 pm-3:10 pm Elaine Da Silva, Ribeirao Preto Medical School, Univ of São Paulo, Brazil
Lympho-epithelial Kazal-type inhibitor (LEKTI) inhibits matriptase-dependent premaligmant phenotype
3:10 pm-3:30 pm  Makiko Kawaguchi, Univ of Miyazaki, Miyazaki, Japan
Accelerated tumor formation induced by HAI-1 deficiency in the ApcMin/+ model is prevented by concomitant deficiency of PAR-2
3:30 pm-3:45 pm Coffee break
3:45 pm-4:05 pm Fausto Varela, Wayne State Univ, Detroit, USA
TMPRSS13 as a modulator of colorectal cancer
4:05 pm-4:25 pm Denis Belitškin, Inst of Biochemistry, Univ of Helsinki, Finland
Type II transmembrane serine protease hepsin is essential for breast cancer cell survival
4:25 pm-4:45 pm Meng Liu, Cyrus Tang Hematology Center, Soochow Univ, Suzhou, China
Human airway trypsin-like protease 4 in acute myeloid leukemia
4:45 pm-5:05 pm Anne Harbig, Inst of Virology, Univ of Marburg, Germany
Distribution of trypsin-like serine proteases in the murine respiratory tract and their putative role in proteolytic activation of influenza A virus
5:05 pm – 6:05 pm Business Meeting, includes poster awards, conference evaluation, organization of 2019 meeting.  All conference participants are requested to attend.
6:05 pm – 8:00 pm Dinner
7:00 am – 8:30 am Final networking breakfast