| THURSDAY, SEPTEMBER 14 |
Click here to view the complete program schedule. |
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| 4:00 pm – 7:30 pm |
Arrivals and meeting check-in |
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| 5:30 pm – 7:15 pm |
Dinner |
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| 7:30 pm – 7:40 pm |
Welcome Remarks |
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| 7:40 pm – 8:40 pm |
Keynote Lecture |
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Toni Antalis, Univ of Maryland, Sch of Med, Baltimore, USA
Novel insights into the role of the membrane-anchored serine protease testisin: From angiogenesis to ovarian cancer |
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| 8:40 pm-10:30 pm |
Welcome Networking Reception |
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| FRIDAY, SEPTEMBER 15 |
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| 7:30 am-8:45 am |
Breakfast
(Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room) |
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| 9:00 am – 12:05 pm |
Session 1: Membrane-Anchored Serine Proteases:Structure, Specificity and Regulation |
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Co-discussion Leaders: Karin List and Signe Thomsen |
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| 9:00 am-9:30 am |
Charles Craik, UCSF, San Francisco, USA
Targeting dynamic protein targets for structural and functional insight |
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| 9:30 am-10:00 am |
Roman Szabo, NIH, Bethesda, USA
Matriptase and prostasin – not your typical proteolytic cascade |
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| 10:00 am-10:30 am |
John Hooper, Mater Research Inst, Univ of Queensland, Australia
Understanding the biology of a protease activated cellular receptor reveals potential avenues for targeting disseminated cancer |
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| 10:30 am-10:45 am |
Coffee break |
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| 10:45 am-11:05 am |
Karl Chai, Univ of Central Florida College of Medicine, USA
What does matriptase not cut? |
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| 11:05 am-11:25 am |
Hannah Limburg, Inst of Virology, Univ of Marburg, Germany
The protease specificity of influenza A virus hemagglutinin monobasic cleavage site in human and murine airway epithelial cells |
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| 11:25 am-11:45 am |
Sébastien Dion, Univ Sherbrooke, Canada
Transcriptome analysis of human livers and cell lines reveals expression of TMPRSS6 isoforms and mutants with altered activity |
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| 11:45 am-12:05 pm |
Can Wang, Soochow Univ, Suzhou, China
Transcriptional regulation of corin expression in the pregnant uterus |
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12:05 pm-1:30 pm &
1:30 pm-2:15 pm |
Lunch &
Free time for networking |
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| 2:30 am-4:00 pm |
Session 2: Membrane-Anchored Serine Proteases: Biosynthesis, Trafficking and Cellular Mechanisms |
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Co-discussion Leaders: Roman Szabo and Hao Wang |
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| 2:30 pm-3:00 pm |
Chen-Yong Lin, Georgetown Univ, Washington DC, USA
Matriptase life cycle features three distinct peptide bond cleavages |
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| 3:00 pm-3:20 pm |
Annika Nonboe, Univ of Copenhagen, Denmark
HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase |
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| 3:20 pm-3:40 pm |
Dongeun Park, Seoul National Univ, Seoul, South Korea
JNK inhibitor-induced ectodomain shedding of Prss14/epithin is mediated by PKCβII and TACE translocation to the membrane |
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| 3:40 pm-4:00 pm |
Moon Kim, Inha Univ, Incheon, South Korea
Epithin/Prss14 intercellular domain released by the regulated intramembrane proteolysis is a transcriptional regulator of cell migration and invasion |
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| 4:00 pm-4:15 pm |
Coffee break |
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| 4:15 pm-6:05 pm |
Session 3: Membrane-Anchored Serine Proteases in Development and Physiology |
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Co-discussion Leaders: Kiroaki Kataoka and Stine Friis |
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| 4:15 pm-4:45 pm |
Shaun Coughlin, UCSF, San Francisco, USA
Roles of Protease-Activated Receptor-2 activity in Zebrafish skin–– a model epithelial tissue |
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| 4:45 pm-5:15 pm |
Eric Camerer, INSERM, Paris, France
PAR2 signaling by membrane-anchored serine proteases: mechanisms of engagement and developmental consequences |
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| 5:15 pm-5:45 pm |
Edith Hummler, Univ of Lausanne, Switzerland
Regulation of ENaC by channel-activating proteases |
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| 5:45 pm-6:05 pm |
Ce Zhang, Soochow Univ, Suzhou, China
Molecular studies of corin expression in the apical membrane of polarized renal epithelial cells |
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| 6:05 pm-7:15 pm |
Dinner |
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| 7:30 pm-10:00 pm |
Poster Session and Reception |
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| SATURDAY, SEPTEMBER 16 |
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| 7:30 am – 8:45 am |
Breakfast
(Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room) |
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| 9:00 am-12:15 pm |
Session 4: Membrane-Anchored Serine Proteases in Metabolism and Homeostasis |
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Co-discussion Leaders: Shaun Coughlin and Koji Yamamoto |
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| 9:00 am-9:30 am |
Delphine Meynard, INSERM, Toulouse, France
Matriptase-2: master regulator of iron homeostasis |
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| 9:30 am-9:50 am |
An-Sheng Zhang, Oregon Health & Science Univ, Portland, USA
Matriptase-2 cleaves multiple components of the hepcidin induction pathway to suppress hepcidin expression |
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| 9:50 am-10:10 am |
Hiroaki Kataoka, Faculty of Medicine, Univ of Miyazaki, Japan
HAI-2 is essential for the maintenance of intestinal epithelium in mice |
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| 10:10 am-10:30 am |
Chuan-Jin Wu, National Cancer Institute, NIH, Bethesda, USA
HAI-2, Matriptase, EpCAM and Claudin-7 coordinately regulate intestinal epithelial homeostasis |
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| 10:30 am-10.45 am |
Coffee break |
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| 10:45 am-11:15 am |
Thomas R. Kleyman, Univ of Pittsburg. USA
Proteases and epithelial sodium channels: Translating basic findings to the bedside |
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| 11:15 am-11:35 am |
Stine Friis, NIH, USA and Univ of Copenhagen, Denmark
Matriptase zymogen supports epithelial development, homeostasis and regeneration |
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| 11:35 am-11:55 am |
Jehng-Kang Wang, National Defense Medical Center, Taipei, Taiwan
Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death |
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| 11:55 am-12:15 pm |
Robert A. Lazarus, Genentech, Inc.
Mechanism of Allosteric Activation of Tryptase: Dual Functionality of Tryptase Protomers as Both Proteases and Cofactors |
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| 12:15 pm – 1:45 pm |
Lunch and networking |
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| 2:00 pm-5:10 pm |
Session 5: Membrane-Anchored Serine Proteases in Cancer and Host Defense |
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Co-discussion Leaders: Charles Craik and Gregory Conway |
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| 2:00 pm-2:30 pm |
James Janetka, Washington Univ, St. Louis, USA
Resistance to anticancer therapy derived from serine protease activation of growth factors |
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| 2:30 pm-2:50 pm |
Gregory Conway, Univ of Maryland, Baltimore, USA
Expression of testisin reduces ovarian tumor metastasis through a PAR-2-angiopoietin signaling pathway |
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| 2:50 pm-3:10 pm |
Elaine Da Silva, Ribeirao Preto Medical School, Univ of São Paulo, Brazil
Lympho-epithelial Kazal-type inhibitor (LEKTI) inhibits matriptase-dependent premaligmant phenotype |
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| 3:10 pm-3:30 pm |
Makiko Kawaguchi, Univ of Miyazaki, Miyazaki, Japan
Accelerated tumor formation induced by HAI-1 deficiency in the ApcMin/+ model is prevented by concomitant deficiency of PAR-2 |
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| 3:30 pm-3:45 pm |
Coffee break |
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| 3:45 pm-4:05 pm |
Fausto Varela, Wayne State Univ, Detroit, USA
TMPRSS13 as a modulator of colorectal cancer |
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| 4:05 pm-4:25 pm |
Denis Belitškin, Inst of Biochemistry, Univ of Helsinki, Finland
Type II transmembrane serine protease hepsin is essential for breast cancer cell survival |
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| 4:25 pm-4:45 pm |
Meng Liu, Cyrus Tang Hematology Center, Soochow Univ, Suzhou, China
Human airway trypsin-like protease 4 in acute myeloid leukemia |
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| 4:45 pm-5:05 pm |
Anne Harbig, Inst of Virology, Univ of Marburg, Germany
Distribution of trypsin-like serine proteases in the murine respiratory tract and their putative role in proteolytic activation of influenza A virus |
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| 5:05 pm – 6:05 pm |
Business Meeting, includes poster awards, conference evaluation, organization of 2019 meeting. All conference participants are requested to attend. |
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| 6:05 pm – 8:00 pm |
Dinner |
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| SUNDAY, SEPTEMBER 17 |
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| 7:00 am – 8:30 am |
Final networking breakfast |
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Departures |