THURSDAY, SEPTEMBER 14 |
Click here to view the complete program schedule. |
|
|
4:00 pm – 7:30 pm |
Arrivals and meeting check-in |
|
|
5:30 pm – 7:15 pm |
Dinner |
|
|
7:30 pm – 7:40 pm |
Welcome Remarks |
|
|
7:40 pm – 8:40 pm |
Keynote Lecture |
|
|
|
Toni Antalis, Univ of Maryland, Sch of Med, Baltimore, USA Novel insights into the role of the membrane-anchored serine protease testisin: From angiogenesis to ovarian cancer |
|
|
8:40 pm-10:30 pm |
Welcome Networking Reception |
|
|
FRIDAY, SEPTEMBER 15 |
|
|
|
7:30 am-8:45 am |
Breakfast (Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room) |
|
|
9:00 am – 12:05 pm |
Session 1: Membrane-Anchored Serine Proteases:Structure, Specificity and Regulation |
|
Co-discussion Leaders: Karin List and Signe Thomsen |
|
|
9:00 am-9:30 am |
Charles Craik, UCSF, San Francisco, USA Targeting dynamic protein targets for structural and functional insight |
|
|
9:30 am-10:00 am |
Roman Szabo, NIH, Bethesda, USA Matriptase and prostasin – not your typical proteolytic cascade |
|
|
10:00 am-10:30 am |
John Hooper, Mater Research Inst, Univ of Queensland, Australia Understanding the biology of a protease activated cellular receptor reveals potential avenues for targeting disseminated cancer |
|
|
10:30 am-10:45 am |
Coffee break |
|
|
10:45 am-11:05 am |
Karl Chai, Univ of Central Florida College of Medicine, USA What does matriptase not cut? |
|
|
11:05 am-11:25 am |
Hannah Limburg, Inst of Virology, Univ of Marburg, Germany The protease specificity of influenza A virus hemagglutinin monobasic cleavage site in human and murine airway epithelial cells |
|
|
11:25 am-11:45 am |
Sébastien Dion, Univ Sherbrooke, Canada Transcriptome analysis of human livers and cell lines reveals expression of TMPRSS6 isoforms and mutants with altered activity |
|
|
11:45 am-12:05 pm |
Can Wang, Soochow Univ, Suzhou, China Transcriptional regulation of corin expression in the pregnant uterus |
|
|
12:05 pm-1:30 pm & 1:30 pm-2:15 pm |
Lunch & Free time for networking |
|
|
2:30 am-4:00 pm |
Session 2: Membrane-Anchored Serine Proteases: Biosynthesis, Trafficking and Cellular Mechanisms |
|
Co-discussion Leaders: Roman Szabo and Hao Wang |
|
|
2:30 pm-3:00 pm |
Chen-Yong Lin, Georgetown Univ, Washington DC, USA Matriptase life cycle features three distinct peptide bond cleavages |
|
|
3:00 pm-3:20 pm |
Annika Nonboe, Univ of Copenhagen, Denmark HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase |
|
|
3:20 pm-3:40 pm |
Dongeun Park, Seoul National Univ, Seoul, South Korea JNK inhibitor-induced ectodomain shedding of Prss14/epithin is mediated by PKCβII and TACE translocation to the membrane |
|
|
3:40 pm-4:00 pm |
Moon Kim, Inha Univ, Incheon, South Korea Epithin/Prss14 intercellular domain released by the regulated intramembrane proteolysis is a transcriptional regulator of cell migration and invasion |
|
|
4:00 pm-4:15 pm |
Coffee break |
|
|
4:15 pm-6:05 pm |
Session 3: Membrane-Anchored Serine Proteases in Development and Physiology |
|
Co-discussion Leaders: Kiroaki Kataoka and Stine Friis |
|
|
4:15 pm-4:45 pm |
Shaun Coughlin, UCSF, San Francisco, USA Roles of Protease-Activated Receptor-2 activity in Zebrafish skin–– a model epithelial tissue |
|
|
4:45 pm-5:15 pm |
Eric Camerer, INSERM, Paris, France PAR2 signaling by membrane-anchored serine proteases: mechanisms of engagement and developmental consequences |
|
|
5:15 pm-5:45 pm |
Edith Hummler, Univ of Lausanne, Switzerland Regulation of ENaC by channel-activating proteases |
|
|
5:45 pm-6:05 pm |
Ce Zhang, Soochow Univ, Suzhou, China Molecular studies of corin expression in the apical membrane of polarized renal epithelial cells |
|
|
6:05 pm-7:15 pm |
Dinner |
|
|
7:30 pm-10:00 pm |
Poster Session and Reception |
|
|
SATURDAY, SEPTEMBER 16 |
|
|
|
7:30 am – 8:45 am |
Breakfast (Commuter attendees are welcome to enjoy the continental breakfast at the break station outside the session room) |
|
|
9:00 am-12:15 pm |
Session 4: Membrane-Anchored Serine Proteases in Metabolism and Homeostasis |
|
Co-discussion Leaders: Shaun Coughlin and Koji Yamamoto |
|
|
9:00 am-9:30 am |
Delphine Meynard, INSERM, Toulouse, France Matriptase-2: master regulator of iron homeostasis |
|
|
9:30 am-9:50 am |
An-Sheng Zhang, Oregon Health & Science Univ, Portland, USA Matriptase-2 cleaves multiple components of the hepcidin induction pathway to suppress hepcidin expression |
|
|
9:50 am-10:10 am |
Hiroaki Kataoka, Faculty of Medicine, Univ of Miyazaki, Japan HAI-2 is essential for the maintenance of intestinal epithelium in mice |
|
|
10:10 am-10:30 am |
Chuan-Jin Wu, National Cancer Institute, NIH, Bethesda, USA HAI-2, Matriptase, EpCAM and Claudin-7 coordinately regulate intestinal epithelial homeostasis |
|
|
10:30 am-10.45 am |
Coffee break |
|
|
10:45 am-11:15 am |
Thomas R. Kleyman, Univ of Pittsburg. USA Proteases and epithelial sodium channels: Translating basic findings to the bedside |
|
|
11:15 am-11:35 am |
Stine Friis, NIH, USA and Univ of Copenhagen, Denmark Matriptase zymogen supports epithelial development, homeostasis and regeneration |
|
|
11:35 am-11:55 am |
Jehng-Kang Wang, National Defense Medical Center, Taipei, Taiwan Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death |
|
|
11:55 am-12:15 pm |
Robert A. Lazarus, Genentech, Inc. Mechanism of Allosteric Activation of Tryptase: Dual Functionality of Tryptase Protomers as Both Proteases and Cofactors |
|
|
12:15 pm – 1:45 pm |
Lunch and networking |
|
|
2:00 pm-5:10 pm |
Session 5: Membrane-Anchored Serine Proteases in Cancer and Host Defense |
|
Co-discussion Leaders: Charles Craik and Gregory Conway |
|
|
2:00 pm-2:30 pm |
James Janetka, Washington Univ, St. Louis, USA Resistance to anticancer therapy derived from serine protease activation of growth factors |
|
|
2:30 pm-2:50 pm |
Gregory Conway, Univ of Maryland, Baltimore, USA Expression of testisin reduces ovarian tumor metastasis through a PAR-2-angiopoietin signaling pathway |
|
|
2:50 pm-3:10 pm |
Elaine Da Silva, Ribeirao Preto Medical School, Univ of São Paulo, Brazil Lympho-epithelial Kazal-type inhibitor (LEKTI) inhibits matriptase-dependent premaligmant phenotype |
|
|
3:10 pm-3:30 pm |
Makiko Kawaguchi, Univ of Miyazaki, Miyazaki, Japan Accelerated tumor formation induced by HAI-1 deficiency in the ApcMin/+ model is prevented by concomitant deficiency of PAR-2 |
|
|
3:30 pm-3:45 pm |
Coffee break |
|
|
3:45 pm-4:05 pm |
Fausto Varela, Wayne State Univ, Detroit, USA TMPRSS13 as a modulator of colorectal cancer |
|
|
4:05 pm-4:25 pm |
Denis Belitškin, Inst of Biochemistry, Univ of Helsinki, Finland Type II transmembrane serine protease hepsin is essential for breast cancer cell survival |
|
|
4:25 pm-4:45 pm |
Meng Liu, Cyrus Tang Hematology Center, Soochow Univ, Suzhou, China Human airway trypsin-like protease 4 in acute myeloid leukemia |
|
|
4:45 pm-5:05 pm |
Anne Harbig, Inst of Virology, Univ of Marburg, Germany Distribution of trypsin-like serine proteases in the murine respiratory tract and their putative role in proteolytic activation of influenza A virus |
|
|
5:05 pm – 6:05 pm |
Business Meeting, includes poster awards, conference evaluation, organization of 2019 meeting. All conference participants are requested to attend. |
|
|
6:05 pm – 8:00 pm |
Dinner |
|
|
SUNDAY, SEPTEMBER 17 |
|
|
|
7:00 am – 8:30 am |
Final networking breakfast |
|
|
|
Departures |