• SpecSymp3

Evolution and Core Processes in Gene Expression


July 13 - 16, 2017, Kansas City, MO
Organized by:
Julia Zeitlinger, Stowers Inst.; David Arnosti, Michigan State Univ.; Justin Fay, Washington Univ. in St. Louis

Meeting Description 

Evolutionary processes operate at all levels of gene expression, and increasingly detailed mechanistic understanding has provided rich hunting grounds for pathways and processes which underlie evolutionary variation, providing the molecular explanation for the beaks of Darwin’s finches, for example. Most studies that have tracked down detailed molecular changes linked to the evolution of morphological variation have highlighted the importance of cis-­‐regulatory variation, as well as changes to sequence-­‐ specific transcription factors. Such changes are expected to have less pleiotropic effects than alterations in the core transcriptional machinery, however new evidence points to high levels of complexity in what was initially assumed to be conserved core transcription machinery, suggesting that variation in these components are likely to play similar roles in evolutionary variation. Similarly, genetic variation in core machinery for protein translation has been shown to be associated with a variety of human diseases, providing a glimpse of the likely variation that underlies population-­‐level differences relevant to studies of “personalized genomics” in humans. 

Important Dates

May 2: Oral programming abstract submission deadline
May 9: Discounted symposium registration deadline
May 24: Poster programming abstract submission deadline
June 8: Symposium registration deadline
June 14: Registration cancellation deadline