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Extracellular Matricies in Health and Disease

Theme organizers:


Jeffrey Gorski
Univ. of
Missouri-Kansas City


Karen Lyons

Interactions of Growth Factors and Integrins with the Extracellular Matrix

Sunday, March 29, 2015, 9:45 AM - 12:00 PM • Room 257A/B

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9:45                        Chair’s Introduction.

9:50      92.1          Integrins Cooperate during Mechanosensing R. Fässler. Max Planck Inst. of Biochem., Martinsried.

10:15                      Trimeric G Protein Activation by the Non-receptor Protein GIV/ Girdin Is Required for Integrin Signaling A. Leyme, L. Perez-Gutierrez, L.T. Nguyen and M. Garcia-Marcos. Boston Univ. (719.5)

10:30    92.2          Members of the CCN Family of Matricellular Proteins are Required for the Formation and Maintenance of Multiple Skeletal Tissues K.M. Lyons. UCLA.

10:55                      Endothelial Deficiency of the Extracellular Matrix Protein CCN1 Alters Developmental and Pathological Angiogenesis B. Chaqour, I. Krupska, L. Yan, L. Lau, M.B. Grant and H. Chintala. SUNY Downstate Med. Ctr., Univ. of Illinois at Chicago and Indiana Univ. (719.2)

11:10                      Extracellular Matrix Fibronectin Attenuates PDGF-Induced Intracellular Calcium Release C.S. Farrar and D.C. Hocking. Univ. of Rochester. (719.3) 

11:25    92.3          Engineering Interactions between Growth Factors and the Extracellular Matrix J.A. Hubbell, M.M. Martino, P.S. Briquez, W.W. Kilarski, E. Guc and M.A. Swartz. Univ. of Chicago and Swiss Fed. Inst. of Technol. Lausanne.

11:50      Discussion. 

Effects of Enzymatic Modification of Extracellular Matrix Proteins

Monday, March 30, 2015, 3:55 PM - 6:10 PM • Room 257A/B

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3:55                        Chair’s Introduction.

4:00      236.1       Wnt Modification by Tiki Proteins X. He. Boston Children’s Hosp. and Harvard Med. Sch.

4:25                        DC-SIGN Binds 2-Fucosyl-Lactose at Concentrations Available in Human Milk R.D. Cummings, Y. Yu, Y. Lasanajak, R. Buck, G. Duska-McEwen, P. Prieto and D.F. Smith. Emory Univ. Sch. of Med. and Abbott Nutr., Columbus. (890.10)

4:40      236.2       The Proprotein Convertases: Cell Surface and Extracellular Matrix Remodeling N.G. Seidah, R. Essalmani, W. Kim, I. Welsh and N.A. Kurpios. IRCM, Clin. Res. Inst. of Montreal and Cornell Univ.

5:05                        Three-Dimensional Collagen IV and Hormone Prolactin Regulate Breast Cancer Cell Invasion: Role of PAK1 and Matrix Metalloproteinases M. Diakonova, P. Oladimeji and L. Rider. Univ. of Toledo. (719.1)

5:20                        Fibroblast-Macrophage Interactions: Regulation by Modification of Extracellular Matrix A. Mazur, T. Kelly and S.R. Post. Univ. of Arkansas for Med. Sci. (719.6)

5:35      236.3       MMPs as Regulators of Tumor Microenvironment Z. Werb. UCSF.

6:00                        Discussion.

Regulation of Stem Cell Niches by the Extracellular Matrix

Tuesday, March 31, 2015, 9:45 AM - 12:00 PM • Room 257A/B

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9:45                        Chair’s Introduction.

9:50      359.1       ECM Remodeling Events during EC-Pericyte Tube Co-assembly in 3D Matrices G.E. Davis. Univ. of Missouri Sch. of Med.

10:15                      Deletion of Integrin-Associated CD151 Impairs Branching Morphogenesis and Activity of Progenitor Cells in the Mammary Gland X. Yang and L.A. Baldwin. Univ. of Kentucky. (890.15)

10:30    359.2       Mesenchymal Stem Cells: Diseases and Cure S. Shi. Univ. of Pennsylvania Sch. of Dent. Med.

10:55                      Investigating Laminin-α3β3γ2’s Potential Role in Epithelial-to-Mesenchymal Transition in Pulmonary Epithelia J.A. David, B.A. Blakeney and R.L. Heise. Virginia Commonwealth Univ. (719.17)

11:10                      A Laminin 511 Matrix is Regulated by TAZ and Functions as the Ligand for the a6Bb1 Integrin to Sustain Breast Cancer Stem Cells   A. Mercurio  UMASS Med. Sch., Worcester, MA (890.4)

11:25    359.3       Proteolytic Remodeling of the 3D Extracellular Matrix Controls the Nuclear Regulation of Mesenchymal Stem Cell Fate and Function S.J. Weiss. Univ. of Michigan.

11:50                      Discussion.

Function of the Extracellular Matrix in Development and Disease 
This session is jointly sponsored by ASBMB and AAA 

Wednesday, April 1, 2015, 1:15 PM - 3:30 PM • Room 257A/B

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1:15                        Chair’s Introduction.

1:20      495.1       Recessive Forms of Osteogenesis Imperfecta and Implications for Mechanisms of Disease P.H. Byers. Univ. of Washington.

1:45                        Cargo Receptor Traffics Many Matrix Proteins Out of the Endoplasmic Reticulum by Binding to N-Terminal IleProVal-Like Motif Y. Yin, M.R. Garcia, A. Novak and L.W. Fisher. NIDCR, NIH. (719.12)

2:00      495.2       Crosstalk between Bone and Muscle: Deletion of Mbtps1 in Bone Leads to Age-Dependent Increase in Muscle Size and Contractile Function J.P. Gorski, N.T. Huffman, N.G. Seidah, L. Bonewald and M. Brotto. Sch. of Dent., Univ. of Missouri-Kansas City, Inst. of Res. Clins. of Montreal and Sch. of Nursing and Hlth. Studies, Univ. of Missouri-Kansas City.

2:25                        SUN2 Accumulation Contributes to Vascular Smooth Muscle Cell Alterations Induced by Matrix Rigidity N. Bélaadi, G. Chadeuf, L. Nguyen, M. Rio, G. Louarn, G. Loirand and C. Guilluy. INSERM, Nantes and CNRS, Univ. of Nantes. (719.20)

2:40                        Role of CD47 in Triple Negative Breast Cancer S. Kaur, S.P. Singh, A.G. Elkahloun, W. Wu, T. Song, A. Arora and D.D. Roberts. NCI, NIH, NIAID, NIH and NHGRI, NIH. (890.5)

2:55      495.3       Mechanisms of FGF-Mediated Morphogenesis R. Marcucio. UCSF.

3:20                        Discussion.