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DNA Replication and Repair

Theme organizers:

Michael G. Fried
Univ. of Kentucky
  Myron F. Goodman

Engaging Stalled Replication Forks           

Sunday, March 29, 2015, 3:55 PM - 6:10 PM • Room 258B

 Follow the conversation: #DNA

Chaired: M. G. Fried

3:55        Chair’s Introduction.

4:00    108.1    Mechanisms for Translesion DNA Synthesis W. Yang, Y. Lee, Y. Gao and M.T. Gregory. NIDDK, NIH.

4:25        Incision-Independent Repair of a Psoralen-Interstrand Crosslink J. Zhang, M. Budzowska and J. Walter. Harvard Med. Sch. and HHMI. (560.14)

4:40    108.2    The Rev1-Pol ζ Mutasome P.M.J. Burgers, A.V. Makarova and S.K. Binz. Washington Univ. Sch. of Med.

5:05        Biochemical Mechanism for Recruitment of the Checkpoint Activator TOPBP1 to Stalled Replication Forks M. Michael. Univ. of So. California. (560.12)

5:20        Dampening Checkpoint Signaling via Coordinated Action of DNA Repair Scaffolds and the Pph3 Phosphatase C.M. Jablonowski, J.R. Cussiol, S.L. Oberly and M.B. Smolka. Cornell Univ. (879.24)

5:35    108.3    Mutations for Worse or Better: Low Fidelity DNA Synthesis by SOS DNA Polymerase V Is a Tightly-Regulated Double-Edged Sword M.F. Goodman, A.L. Erdem, M. Jaszczur, J.G. Bertram, R. Woodgate and M.M. Cox. Univ. of So. California, NICHD, NIH and Univ. of Wisconsin-Madison.

6:00        Discussion.

Super-resolution Replication Studies

Monday, March 30, 2015, 9:45 AM - 12:00 PM • Room 258B

Follow the conversation: #DNA

Chaired: M. F. Goodman

9:45        Chair’s Introduction.

9:50        Stochastic Activation of a DNA Damage Response Causes Cell-to-Cell Variation in Mutation Rates S. Uphoff. Univ. of Oxford.

10:15        A Single-Molecule Reconstitution of Translesion Synthesis and Competition between DNA Polymerases J.E. Kath, S. Jergic, J.M. Heltzel, D.T. Jacob, N.E. Dixon, M.D. Sutton, G.C. Walker and J.J. Loparo. Harvard Med. Sch., MIT, Univ. at Buffalo and Univ. of Wollongong, Australia. (561.6)

10:30    225.2    A Unified Picture of Nucleotide Selection by a High Fidelity DNA Polymerase I L. Beese, W. Wang and H.W. Hellinga. Duke Univ.

10:55        Checkpoint Regulation of Replication Forks at Sites of DNA Damage D.R. Iyer and N.R. Rhind. UMass Med. Sch. (560.13)

11:10        Multi-color, Live Cell CRISPR-Based 3-D Mapping of the Human Nuclear Genome H. Ma, A. Neseri, P. Reyes-Gutierrez, S. Zhang, S.A. Wolfe and T. Pederson. UMass Med. Sch. and Univ. of Central Florida. (710.3)

11:25    225.3    In vivo Single-Molecule Studies of DNA Repair in E. coli A.M. van Oijen. Univ. of Wollongong, Australia.

11:50        Discussion.

DNA Topology and Repair

Tuesday, March 31, 2015, 3:55 PM - 6:10 PM • Room 258B

Follow the conversation: #DNA

Chaired: L. Lindsey-Boltz

3:55        Chair’s Introduction.

4:00    371.1    Visualizing Replication and Recombination on Single Molecules of DNA S. Kowalczykowski. Univ. of California, Davis.

4:25        CTCF Protein Recruits Centromeric Protein CENP-E to the Centromeric Regions through Unusual CTCF Binding Sites T. Xiao, P. Wongtrakoongate, C. Trainor and G. Felsenfeld. NIDDK, NIH. (709.6)

4:40    371.2    Tying Up the Ends: Recognition of ssDNA at Telomeres D.S. Wuttke and T.H. Dickey. Univ. of Colorado Boulder.

5:05        Base Flipping in Lesion Search and Recognition by the Human Thymine DNA Glycosylase Revealed by Single Molecule Imaging I. Tessmer, C.N. Buechner, A. Maiti and A. Drohat. Univ. of Wuerzburg and Univ. of Maryland Baltimore. (879.11)

5:20        Nucleosome Dynamics around a DNA Double Stranded Break during Repair by Gene Conversion M. Tsabar, W.M. Hicks and J.E. Haber. Brandeis Univ. and Harvard Med. Sch. (709.8)

5:35    371.3    Topoisomerase-Induced DNA Cleavage at Ribonucleotide Misincorporation Sites Y. Pommier, S-Y. Huang, J.S. Williams and T.A. Kunkel. NCI, NIH and NIEHS, NIH.

6:00        Discussion.

Cooperativity and Crosstalk

Wednesday, April 1, 2015, 9:00 AM - 11:15 AM • Room 258B

Follow the conversation: #DNA

Chaired: D. S. Wuttke

9:00        Chair’s Introduction.

9:05    490.1    Coupling of Human DNA Excision Repair and the ATR-Mediated DNA Damage Checkpoint L. Lindsey-Boltz, M.G. Kemp, J.T. Reardon, V. DeRocco, R.R. Iyer, P. Modrich and A. Sancar. Univ. of North Carolina at Chapel Hill Sch. of Med. and Duke Univ. Med. Ctr.

9:30        Non-cognate DNA Damage Prevents Formation of Active Conformation of Y-Family DNA Polymerases DinB and Pol Kappa P. Nevin, X. Lu, K. Zhang, J.R. Engen and P.J. Beuning. Northeastern Univ. (561.8)

9:45    490.2    A New Look at Transcription-Coupled DNA Repair E. Nudler, V. Epshtein, V. Kamarthapu, V. Svetlov and K. McGary. NYU Sch. of Med., HHMI.

10:10        ATR Promotes the Replication Traverse of DNA Interstrand Crosslinks J. Huang, M. Bellani, Y. Xue, W. Wang, A.R. Meetei and M.M. Seidman. NIA, NIH, Baltimore and Cincinnati Children’s Hosp. Med. Ctr. (560.9)

10:25        The Role of Histone H1 in S. cerevisiae R. Leicher, S. Schilit and S. Holmes. Wesleyan Univ. (709.4)

10:40    490.3    Crosstalk In DNA-Alkyltransferase Functions M.G. Fried and I. Tessmer. Univ. of Kentucky and Univ. of Würzburg.

11:05        Discussion.