ASBMB News (RSS)



JBC Thematic Minireview Series: Cell Biology of G-Protein Signaling

January 20, 2015 — This thematic series is on the topic of cell signaling from a cell biology perspective, with a particular focus on G proteins. Authors discuss biosensors that are being used to monitor G protein signaling events in live cells, the implementation of antibody-based biosensors to dissect endosome signaling by G proteins and their receptors, and the function of a non-receptor, cytoplasmic activator of G protein signaling, called GIV (Girdin). Collectively the advances described in these articles provide a deeper understanding and emerging opportunities for new pharmacology.

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JBC Thematic Minireview Series: Radical SAM Enzymes

December 5, 2014 — In this thematic minireview series, the JBC presents six articles on radical SAM enzymes that accomplish wide-ranging chemical transformations. We learn that despite the diversity of the reactions catalyzed, family members share some common structural and mechanistic themes. Still in its infancy, continued explorations promise to be fertile grounds for discoveries that will undoubtedly further broaden our understanding of the catalytic repertoire and deepen our understanding of the chemical strategies used by radical SAM enzymes.

Read all of the articles in this series here  

JBC Thematic Minireview Series: Nutrient Regulation of Cellular Metabolism & Physiology by O-GlcNAcylation

November 4, 2014 — The dynamic cycling of N-acetylglucosamine (termed O-GlcNAcylation) on serine or threonine residues of nuclear or cytoplasmic proteins serves as a nutrient sensor, both independently and also via its interplay with other post-translational modifications, to regulate signaling, transcription and cell physiology. Emerging evidence suggests that dysregulation of this ubiquitous post-translational modification contributes to the etiology of some the most important human chronic diseases. This Thematic Series provides an overview of our current knowledge about the myriad roles of O-GlcNAcylation in cellular physiology.

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JBC Thematic Minireview Series: Metals in Biology 2014

September 2, 2014 — This thematic series addresses the issue of why certain metals are used by particular enzymes, as well as the consequences of using the wrong metal. The first Minireview in the series deals with general aspects of metal specificity, and the next two deal with specific cases, the enzyme ribonucleotide reductase and iron/manganese homeostasis in the bacterium Bacillus subtilis. The fourth discusses with metal selection in oxidative stress, and the final organelles (lysomes) as mediators of metal homeostasis.

Read all of the articles in this series here  

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