JBC Thematic Minireview Series - Metals at the Host-Pathogen Interface

June 9, 2015 — This seventh Metals in Biology Thematic Series deals with the metal-based interactions of mammalian hosts with pathogens. Both pathogens and host have complex regulatory systems for metal homeostasis. Understanding these provides strategies for fighting pathogens, either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms. Intervention is possible by delivery of complexing reagents or by targeting the microbial regulatory apparatus.

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JBC Thematic Minireview Series: The State of the Cytoskeleton in 2015

May 15, 2015 — The study of cytoskeletal polymers has been an active area of research for more than 70 years. Yet, despite decades of pioneering work by some of the brightest scientists in biochemistry, cell biology and physiology, many central questions regarding the polymers themselves are only now starting to be answered. In this thematic series of mini-reviews, these topics are covered by some of the very same scientists who generated these recent insights, thereby providing us with an overview of the State of the Cytoskeleton in 2015.

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JBC Thematic Series - Novel Bioactive Sphingolipids

May 15, 2015 — Sphingosine was named by J.L.W. Thudichum for its enigmatic properties. This descriptor has applied to sphingolipids for over a century because new enigmas continue to surface. This JBC minireview series presents articles about three novel subspecies of sphingolipids — α-galactosylceramides, 4,5-dihydroceramides and 1-deoxysphingolipids — that have important activities but, until recently, remained undetected (or at least understudied) in the shadow of very closely related compounds. They also serve as a reminder that important metabolites still lie "off the radar screen" in reports of global and comprehensive metabolomic profiling.

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JBC Thematic Minireview Series: Cell Biology of G-Protein Signaling

January 20, 2015 — This thematic series is on the topic of cell signaling from a cell biology perspective, with a particular focus on G proteins. Authors discuss biosensors that are being used to monitor G protein signaling events in live cells, the implementation of antibody-based biosensors to dissect endosome signaling by G proteins and their receptors, and the function of a non-receptor, cytoplasmic activator of G protein signaling, called GIV (Girdin). Collectively the advances described in these articles provide a deeper understanding and emerging opportunities for new pharmacology.

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