JBC Thematic Series - Metals in Biology: alpha-Ketoglutarate and Iron Dependent Dioxygenases

July 14, 2015 — Four Minireviews deal with aspects of the α-ketoglutarate/iron dependent dioxygenases in this eighth Thematic Series on Metals in Biology. The Minireviews cover a general introduction and synopsis of the current understanding of mechanisms of catalysis, the roles of these dioxygenases in post-translational protein modification and de-modification, the roles of the ten-eleven translocation (Tet) dioxygenases in the modification of methylated bases (5mC, T) in DNA relevant to epigenetic mechanisms, and the roles of the AlkB-related dioxygenases in the repair of damaged DNA and RNA.

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JBC Thematic Series - New Directions in G Protein-Coupled Receptor Pharmacology

July 14, 2015 — Over the past half century, The Journal of Biological Chemistry has been the venue for many landmark publications on the topic of G protein coupled receptors (GPCRs, also known as 7 transmembrane receptors). The GPCR superfamily in humans is comprised of about 800 members, and is the target of about one third of all pharmaceuticals. Most of these drugs target a very small subset of GPCRs, and do so by mimicking or competing with endogenous hormones and neurotransmitters. This thematic mini-review series examines some emerging trends in GPCR drug discovery.

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JBC Thematic Minireview Series - Metals at the Host-Pathogen Interface

June 9, 2015 — This seventh Metals in Biology Thematic Series deals with the metal-based interactions of mammalian hosts with pathogens. Both pathogens and host have complex regulatory systems for metal homeostasis. Understanding these provides strategies for fighting pathogens, either by excluding essential metals from the microbes, by delivery of excess metals to cause toxicity, or by complexing metals in microorganisms. Intervention is possible by delivery of complexing reagents or by targeting the microbial regulatory apparatus.

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JBC Thematic Minireview Series: The State of the Cytoskeleton in 2015

May 15, 2015 — The study of cytoskeletal polymers has been an active area of research for more than 70 years. Yet, despite decades of pioneering work by some of the brightest scientists in biochemistry, cell biology and physiology, many central questions regarding the polymers themselves are only now starting to be answered. In this thematic series of mini-reviews, these topics are covered by some of the very same scientists who generated these recent insights, thereby providing us with an overview of the State of the Cytoskeleton in 2015.

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