JBC Thematic Review Series: Phospholipase D and Cancer
Phospholipase D signaling plays a critical role in cell growth and
proliferation, vesicular trafficking, secretion and endocytosis. Cancer
invasion and metastasis rely heavily on cellular motility, and, as such,
they have put PLD at center stage in cancer research, as outlined in
this Journal of Biological Chemistry minireview series organized by
Julian Gomez-Cambronero and George M. Carman.
JBC News Podcast: α-synuclein, living cells and Parkinson’s disease: JBC’s best Cell Biology article of 2013
March 10, 2014 — In the last of our four-part podcast series on the best articles of 2013 in the The Journal of Biological Chemistry, we hear about the debate surrounding α-synuclein, which plays a critical role in Parkinson’s disease. Is it an unfolded monomer? Is it a helically-folded tetramer? Paul Fraser, a professor of medical biophysics at the University of Toronto and a JBC associate editor, speaks with Dennis Selkoe, a professor of neurological diseases at Harvard Institutes of Medicine, and Ulf Dettmer, a research fellow in neurology also at Harvard. Selkoe and Dettmer are co-authors of JBC’s best article of 2013 in the Affinity category of Cell Biology. It is titled, “In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells,” and it was published in March. The paper details a new method for cross-linking α-synuclein in living cells that reveals a form consistent with a tetramer. In this conversation, we hear about the prior research leading to this article and what to look forward to as the debate continues.
Click here to read a transcript of this podcast interview.