JBC Thematic Minireview Series - Intrinsically Disordered Proteins

February 5, 2016 — In this thematic minireview series, the JBC presents six exciting articles on low complexity or intrinsically disordered proteins (IDPs). This collection of reviews discusses biophysical approaches for studying IDPs, illuminates their importance to critical functions like cell cycle control, transcription and translation and their regulation via cellular input signals.

Read all of the articles in this series here

JBC Thematic Minireview Series - Modern Technologies for In-Cell Biochemistry

December 16, 2015 — The last decade has seen enormous progress in the exploration and understanding of the behavior of molecules in their natural cellular environments at increasingly high spatial and temporal resolution. Advances in microscopy, development of new fluorescent reagents, and genetic editing have enabled quantitative analysis of protein interactions, intracellular trafficking, metabolic changes, and signaling. Modern biochemistry now faces new and exciting challenges. This Thematic Series summarizes recent studies that illustrate some first steps towards successfully answering these modern biochemical questions.

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JBC Thematic Minireview Series: Molecular Mechanisms of Synaptic Plasticity

October 15, 2015 — High fidelity synaptic communication between subsets of neurons in specific circuits is required for most human behaviors, and is often disrupted in neuropsychiatric disorders. This series of mini-reviews focuses on recent advances in our understanding of the molecular and cellular mechanisms that control "synaptic plasticity" leading to changes in overall neuronal circuit activity, resulting in behavioral modifications.

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JBC Thematic Minireview Series: Protein Interactions, Structures, and Networks

September 10, 2015 —  Protein interactions are fundamental to the proper functioning of cells, and aberrant formation or regulation of protein interactions is at the heart of many diseases, including cancer. The advancement of methods to study the identity, function, and regulation of protein complexes makes possible the understanding of how those complexes malfunction in human diseases. This series of minireviews highlights methodological advances and how they have been applied in novel ways to explore the function and regulation of pathways and dynamic networks in cells.

Read all of the articles in this series here

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