JBC News podcast: The N-terminal lobe regulating Argonaute slicer activity: JBC’s best RNA article of 2013
Feb. 17, 2014 — This podcast is the first in a four-part series on the article named the best of 2013 in The Journal of Biological Chemistry. The Journal’s editors reviewed the more than 4,000 articles published throughout the year and named 22 among the best, one article for each of the Journal’s Affinity categories. An affinity category corresponds to a section of the Journal’s table of contents.
In our first podcast, we talk briefly with Rachel Green, a professor in the Department of Molecular Biology and Genetics at Johns Hopkins University School of Medicine. She is the corresponding author of JBC’s Best Article of the Year in the category of RNA. The article is titled Regulation of Argonaute Slicer Activity by Guide RNA 3′ End Interactions with the N-terminal Lobe, and it was published in March. When asked about the paper’s significance, JBC’s editor-in-chief, Martha Fedor, pointed out that RNA interference and microRNA pathways for gene silencing differ their effects on target RNAs and in the structures of the guide RNAs, such as siRNAs and microRNAs, that initiate each pathway. She said this article provides important insight into how recognition of siRNA and microRNA structures by Argonaute proteins influences downstream effects on target RNAs. Dr. Green talked about her work, the way this article came about, and the direction she sees this research moving.
Click here to read a transcript of this podcast interview.
Poultry probiotic’s coat clues to ability to battle bugs
Nov. 19, 2013 — IFR researchers have characterised the coat of a potential poultry probiotic, giving the first clues of how it may be used to exclude pathogenic bacteria from chickens. Now, in research published in The Journal of Biological Chemistry, the researchers present the first characterisation of what makes up this coat. This will give us a better idea of the role of the coat and help in the development of these bacteria as a way of combatting C. perfringens. More...