The cover story for this issue, written by Rajendrani Mukhopadhyay, explores how molecular biologists and clinicians figured out how an enzyme involved in ubiquitination plays a role in a rare, genetic disorder of the immune system. In a Q&A, John Arnst interviews biochemist Michael Wolfgang of Johns Hopkins University about his work in lipid metabolism. There also is an essay from a scientist who describes his battle with alcoholism. As always, the magazine offers a variety of stories, such as journal news, member updates and perspectives.
Read the January issue.