JBC Thematic Minireview Series: Prions

A Minireview series coordinated by Associate Editor Paul E. Fraser

May 23, 2014 — Prions are self-replicating protein aggregates and are the primary causative factor in a number of neurological diseases in mammals. The prion protein (PrP) undergoes a conformational transformation leading to aggregation into an infectious cellular pathogen. Prion-like protein spreading and transmission of aggregates between cells has also been demonstrated for other proteins associated with Alzheimer’s and Parkinson’s disease. This protein-only phenomenon may therefore have broader implications in neurodegenerative disorders. The minireviews in this thematic series highlight the recent advances in prion biology and the role these unique proteins play in disease.

Read all of the articles in this series here