PSI-Structural Genomics
High-Throughput Structural Biology: Enabling Technologies
Sunday, April 25, 12:30 – 2:00 PM
Marriott Hotel (across from Anaheim Convention Center), Elite Ballroom 1-2, Room Change: Platinum 9
Session Chairs: Peter Preusch, Charles Edmonds, and Ward Smith, National Institute of General Medical Sciences
Eaton Lattman, Hauptman-Woodward Medical Research Institute
Crystallography Community – Community Crystallography
Brian Fox, University of Wisconsin
Why not High-Throughput Eukaryotic Protein Structures
Raymond Stevens, The Scripps Research Institute
Technology Development for Membrane Protein Structures
Roland Dunbrack, Fox Chase Cancer Center
If You Can't Be with the One You Love – Can you make a model of it?
Session Wrap-Up: Introduction to PSI Biology
Session Chairpersons
Four-thousand Structures and More on the Wall
– Accomplishments of Structural Genomics and What Has Been Learned
Sunday, April 25, 3:30 – 6:00 PM
Marriott Hotel (across from Anaheim Convention Center), Elite Ballroom 1-2, Room Change: Platinum 9
Session Chairs: Jeremy Berg, Catherine Lewis, Peter Preusch, National Institute of General Medical Sciences
Ian Wilson, The Scripps Research Institute
Metabolic Reconstruction of Thermotoga Maritima – Toward Complete Sequence-Structure-Function Understanding of a Model Organism
Gaetano Montelione, Rutgers University
Targeting Protein-Protein Interaction Networks: Structural Genomics of FeS Cluster Assembly and Human Cancer Biology
Stephen Burley, Eli Lilly and Company
Structural Genomics of Enzyme Superfamilies
Andrzej Joachimiak, Argonne National Laboratory
Metagenomics - the Next Structural Frontier
Michael Levitt, Stanford University
Structural Genomics – When are Enough Structures Enough?
Session Wrap-Up: Introduction to PSI Biology
Session Chairpersons
PSI:Biology High-Throughput Enabled Structural Biology Partnerships
Tuesday, April 27, 12:30 – 2:00 PM
Anaheim Convention Center, Room Change: 304D, Ballroom E, Third Floor
This session will introduce ASBMB members to the new NIGMS sponsored PSI:Biology program. This program is a major restructuring and redirection of the Protein Structure Initiative that has been supported by NIGMS for the past 10 years. The former program focused initially on technology development to establish high-throughput pipelines for efficient protein structure determination. These pipelines were then applied to the problem of understanding the relationship between sequence and structure space (i.e., protein folding and the evolution of protein sequences and protein folds). The PSI:Biology program will apply the new paradigm of highly coordinated effort by a network of structural biologists to other biological problems of interest a broad scientific community. The PSI:Biology network will consist of five components: i) Centers for High-Throughput Structure Determination; ii) Centers for Membrane Protein Structure Determination; iii) Consortia for High-Throughput Enabled Structural Biology Partnerships; iv) PSI-Structural Genomics Knowledgebase and Nature Gateway; v) PSI-Material Repository. The selection of protein targets for structure determination will be defined primarily by the scientific objectives of those scientists who respond to the partnerships announcements. The goal of this session is to explain to potential participants how they can become involved in this program and how it may benefit their research. A panel of researchers and NIH staff members will make brief presentations then field questions from the audience regarding the organization of PSI:Biology and the available Funding Opportunities Announcements.
Jeremy Berg, Director, NIGMS
Peter Preusch, Acting Director, Protein Structure Initiative, NIGMS
Stephen Burley, Eli Lilly and Company
Helen Berman, Rutgers University - PSI Knowledgebase
Josh Labaer, Arizona State University - PSI Material Repository
Susan Taylor, University of California-San Diego
John Gerlt, University of Illinois