Chemical Biology and Drug Discovery Theme

Theme Organizers:
Peter J. Tonge, Stony Brook University and
Adrian Whitty, Metcalf Center for Science and Engineering

Short talks for this theme will be selected from the volunteered abstracts.

(* denotes Session Chair)




Mechanisms of Drug Action
Sunday, April 25
9:55 AM - 12:15 PM, Room 304C

John Blanchard*, Albert Einstein College of Medicine

Jessie English, Merck
Kinase Inhibitor Specificity and Targeting Human Disease


Lizbeth Hedstrom, Brandeis University
Targeting a Prokaryotic Enzyme in a Eukaryotic Pathogen


Peter J. Tonge, Stony Brook University
Slow-Onset Enzyme Inhibition, Residence Time and In Vivo Drug Activity



Drug Development 101
an EB-wide sponsored session
Monday, April 26
12:00 PM - 2:00 PM, Room 204A

This presentation will provide an overview of the drug development process, from early drug discovery to actual clinical (human) trials and discuss regulatory requirements, time lines, strategies and areas of special concern.



Chemical Biology: Dissecting Cellular Processes
Monday, April 26
3:30 PM - 5:50 PM, Room 304C

Donald Hilvert*, ETH, Swiss Federal Institute of Technology Zurich

Joanna S. Fowler, Brookhaven National Laboratory
Imaging Brain Chemistry in Diseases of Addiction


Tom Wandless, Stanford University
General Methods to Conditionally Regulate Protein Function


Adrian Whitty, Metcalf Center for Science and Engineering
Towards An Integrated View of Receptor Signaling



Thematic Reception
Monday, April 26
5:50 PM - 6:30 PM, Third Floor Foyer
Join us immediately following, "Chemical Biology: Dissecting Cellular Processes



Drug Resistance

Tuesday, April 27
9:55 AM -12:15 PM, Room 304C

Peter J. Tonge*, Stony Brook University

John Blanchard, Albert Einstein College of Medicine
Drug Resistance Mechanisms in Mycobacterium tuberculosis


Celia Schiffer, University of Massachusetts Amherst
Combating Drug Resistance: The Balance between Inhibition and Substrate Recognition


Joseph Wu, Pfizer, Inc.
Molecular Mechanisms of Resistance to Imatinib or Sunitinib in KIT Mutants from Patients with Gastrointestinal Stromal Tumors



Chemical Biology: Evolution, Engineering and Design

Wednesday, April 28
1:30 PM - 3:50 PM, Room 304C

Adrian Whitty*, Metcalf Center for Science and Engineering

Frances H. Arnold, California Institute of Technology
How Proteins Adapt: Lessons from Directed Evolution


Donald Hilvert, ETH, Swiss Federal Institute of Technology Zurich
Teaching Old Enzymes New Tricks


Alexey Lugovskoy, Biogen Idec
Engineering of Monovalent, Multivalent and Bispecific Antibodies for New Therapeutic Applications





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