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Recent Podcasts

  • JBC News Podcast: α-synuclein, living cells and Parkinson’s disease: JBC’s best Cell Biology article of 2013March 10, 2014 — In the last of our four-part podcast series on the best articles of 2013 in the The Journal of Biological Chemistry, we hear about the debate surrounding α-synuclein, which plays a critical role in Parkinson’s disease. Is it an unfolded monomer? Is it a helically-folded tetramer? Paul Fraser, a professor of medical biophysics at the University of Toronto and a JBC associate editor, speaks with Dennis Selkoe, a professor of neurological diseases at Harvard Institutes of Medicine, and Ulf Dettmer, a research fellow in neurology also at Harvard. Selkoe and Dettmer are co-authors of JBC’s best article of 2013 in the Affinity category of Cell Biology. It is titled, “In Vivo Cross-linking Reveals Principally Oligomeric Forms of α-Synuclein and β-Synuclein in Neurons and Non-neural Cells,” and it was published in March. The paper details a new method for cross-linking α-synuclein in living cells that reveals a form consistent with a tetramer. In this conversation, we hear about the prior research leading to this article and what to look forward to as the debate continues.
  • JBC News Podcast: Key interactions at the HER2-HER3 kinase dimer interface: JBC’s best Signal Transduction article of 2013March 3, 2014 — In Part Three of our series of the best articles of 2013 in the The Journal of Biological Chemistry, we hear a conversation between Alex Toker, a professor in the Department of Pathology at Beth Israel Deaconess Medical Center, and Ron Bose, a medical oncologist and assistant professor in the Division of Biological and Biomedical Sciences at Washington University in St. Louis. Bose is the corresponding author of the paper “Carboxyl Group Footprinting Mass Spectrometry and Molecular Dynamics Identify Key Interactions in the HER2-HER3 Receptor Tyrosine Kinase Interface.” This paper was named the JBC’s Best Article of 2013 in the category of Signal Transduction. The paper provides the first structural characterization of HER2-HER3 heterodimers, which are part of the receptor family that is used in the development of targeted cancer therapies. Here, Bose talks about his more than 10 years of research in the study of tyrosine kinases. He also talks about where the research is going, the development of innovation where mass spectrometry is limited in the study of protein complexes that can’t be crystalized, and the power of interdisciplinary studies for graduate students in science.
  • JBC News Podcast: Prion-mediated toxicity of Aβ oligomers: JBC’s best Neurobiology article of 2013Feb. 24, 2014 — In this, the second in our four-part podcast series on the best articles of 2013 in The Journal of Biological Chemistry, we hear a conversation between Associate Editor Paul Fraser, a professor in the Department of Medical Biophysics at the University of Toronto, and Nigel Hooper from the Faculty of Biological Sciences at the University of Leeds in the United Kingdom. Dr. Hooper is the author of JBC’s Best Article of 2013 in the category of Neurobiology. It is titled, “Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1,” and it was published in March. The paper focuses attention on how remodeling amyloid-β oligomers and disrupting the prion LRP1 raft interaction can provide therapeutic targets for Alzheimer disease. Drs. Fraser and Hooper talk about the progression of this work and where the research may lead.