On Wednesday, the National Institutes of Health announced the appointment of two key leadership positions at the National Human Genome Research Institute (NHGRI). Dr. Mark S. Guyer becomes the Deputy Director of NHGRI and Dr. James C. Mullikin was named the permanent director of the NIH Intramural Sequencing Center. Both Guyer and Mullikin have a long history with genomics research and the NHGRI.